Synthesis, conformational control, and photothermal application of helically twisted 3,6-carbazole-based porphyrinoids and mono-palladium complex.

Chengming Li, Weihua Zhuang, Yongjie Zhou, Linfeng He, Jiayin Yang, Gang Xu, Rongchuan Su, Mao Chen, Jingsong You

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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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9 authors.

Chengming Li *Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases & Cardiac Structure and Function Research Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0001-8906-2256

Weihua Zhuang *Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases & Cardiac Structure and Function Research Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0003-0492-7527

Yongjie Zhou *Department of Liver Transplantation Center & Institute of Organ Transplantation, West China Hospital, Sichuan University, Chengdu, China.

Linfeng HeDepartment of Liver Transplantation Center & Institute of Organ Transplantation, West China Hospital, Sichuan University, Chengdu, China.

Jiayin YangDepartment of Liver Transplantation Center & Institute of Organ Transplantation, West China Hospital, Sichuan University, Chengdu, China. doctoryjy@scu.edu.cn.ORCID http://orcid.org/0009-0002-7221-4932

Gang XuDepartment of Liver Transplantation Center & Institute of Organ Transplantation, West China Hospital, Sichuan University, Chengdu, China.

Rongchuan SuDepartment of Pharmacology, North Sichuan Medical College, Nanchong, China.

Mao ChenLaboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases & Cardiac Structure and Function Research Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China. chenmao@scu.edu.cn.ORCID http://orcid.org/0009-0007-6008-7944

Jingsong YouKey Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, China. jsyou@scu.edu.cn.ORCID http://orcid.org/0000-0002-0493-2388

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32201147National Natural Science Foundation of China (National Science Foundation of China) 82170375National Natural Science Foundation of China (National Science Foundation of China) 82270691National Natural Science Foundation of China (National Science Foundation of China) U23A20395

6 · The paper itself

Abstract

Synthetic control over multiple conformations of expanded porphyrinoids, which are intrinsically linked to their properties and functions, has long been a key objective in chemical research. Here, we present an N-substituent-controlled synthesis of 3,6-carbazole-based octaphyrins and dodecaphyrins via modified Rothemund-type condensation. The choice of pre-modified N-substituents (hydrogen, methyl, tert-butoxycarbonyl) on the 3,6-carbazolylene precursors critically dictates the assembly pathway, enabling access to porphyrinoids with distinct conformations. The octaphyrin scaffold comprises two figure-eight geometries and a half-twisted Möbius form, shaped by solvent-drived kinetic and thermodynamic control. The dodecaphyrins display two helically twisted topologies governed by thermodynamical control. Metalation with Pd(OAc)₂ stabilizes the dynamic twist of octaphyrin into a specific figure-eight geometry, yielding a mono-Pd

Identifiers

PMID40781222

DOI10.1038/s41467-025-62763-1

PMCPMC12334570

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