ArticleCell death & disease2025
Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a small molecule sensitizing glioblastoma to anti-PD1.
Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Tumor-intrinsic TLR4 signaling as a context-dependent rheostat in glioblastoma.Journal of molecular medicine (Berlin, Germany) · 2026Review
- Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026Review
- CD73Nature communications · 2026Article
- Review
- A machine learning-defined cellular senescence signature systematically enhances prognostication and guides immunotherapy strategies for the treatment of gliomas.NPJ precision oncology · 2026Article
- Ribosomal Protein RPL29 Promotes Hepatocellular Carcinoma Progression Through Regulation the Expression of Exosome Component 4.Biological procedures online · 2026Article
- Research progress on the spatiotemporal dynamics of therapy-induced senescence in remodeling the tumor microenvironment.Frontiers in immunology · 2026Review
- Metabolic reprogramming and immunosenescence: a new sight for glioma therapy.Frontiers in cell and developmental biology · 2026Review
- Towards a personalized perspective on gliomas: an epigenetic-immuno-inflammatory aging framework.Frontiers in immunology · 2026Review
- PCK2, a SASP-Associated Gene, Serves as an Independent Prognostic Indicator in Diffuse Large B-Cell Lymphoma.Journal of inflammation research · 2025Article
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Authors and funding
6 authors.
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Abstract
Senescence-associated secretory phenotype (SASP) in cancer refers to the bioactive secretome produced by senescence cells in the tumor microenvironment, which could be triggered by therapeutics or local stress conditions. Here, we provided a SASP Score in glioblastoma (GBM) with generating a SASP gene panel to identify the potential small molecular candidate targeting SASP in GBM. The effectiveness of this scoring method was firstly interrogated with our in-house GBM cohort and public datasets, including transcriptomic data from bulk and single cell GBM samples. Then, we validate this score with functional assays and transcriptomic profiling of Doxorubicin-induced senescence GBM cells. Multi-omics profiling with this score demonstrates that SASP facilitates IDH wild type glioma progression by modulating both the behaviors of malignant cells and tumor associated macrophages (TAMs), and discloses GDC-0879 as a feasible SASP inhibitor in GBM therapy. Its administration not only attenuates the tumorigenicity of GBM cells, but also sensitizes GBM to anti-PD1 in preclinical mouse models. Together, we provide a SASP evaluation approach in glioma, and use it to highlight the critical role of SASP in GBM progression and demonstrate GDC-0879 as a small molecule impairing GBM tumorigenicity and improving their response to anti-PD1. Created by Figdraw ( www.figdraw.com ).
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