Evidence map›Paper›PMID 40781220›Full record

ArticleTranslational stroke research2025

Comprehensive Venous Outflow Evaluation Predicts Stroke Outcome After Optimal Endovascular Ischemic Stroke Treatment.

Francesco Favruzzo, Lorena Nico, Alvise Fattorello Salimbeni, Marco Falda, Alessandra Pes, Ludovica De Rosa, Matteo Zaccagnino, Federica Viaro, Alessio Pieroni, Stefano Mozzetta and 5 more

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Article in Translational stroke research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Francesco FavruzzoDepartment of Neurology and Stroke Center, Padua University Hospital, University of Padua, Via Nicolò Giustiniani 2, 35128, Padua, Italy.
Lorena NicoDepartment of Neuroradiology, Padua University Hospital, University of Padua, Via Nicolò Giustiniani 2, 35128, Padua, Italy.
Alvise Fattorello SalimbeniDepartment of Neurology and Stroke Center, Padua University Hospital, University of Padua, Via Nicolò Giustiniani 2, 35128, Padua, Italy.
Marco FaldaDepartment of Neurosciences, University of Padova, Via Giustiniani, 5, 35128, Padua, Italy.
Alessandra PesDepartment of Neurology and Stroke Center, Padua University Hospital, University of Padua, Via Nicolò Giustiniani 2, 35128, Padua, Italy.
Ludovica De RosaDepartment of Neurology and Stroke Center, Padua University Hospital, University of Padua, Via Nicolò Giustiniani 2, 35128, Padua, Italy.
Matteo ZaccagninoDepartment of Neurology and Stroke Center, Padua University Hospital, University of Padua, Via Nicolò Giustiniani 2, 35128, Padua, Italy.
Federica ViaroDepartment of Neurology and Stroke Center, Padua University Hospital, University of Padua, Via Nicolò Giustiniani 2, 35128, Padua, Italy.
Alessio PieroniDepartment of Neurology and Stroke Center, Padua University Hospital, University of Padua, Via Nicolò Giustiniani 2, 35128, Padua, Italy.
Stefano MozzettaDepartment of Neurology and Stroke Center, Padua University Hospital, University of Padua, Via Nicolò Giustiniani 2, 35128, Padua, Italy.
Joseph Domenico GabrieliDepartment of Neuroradiology, Padua University Hospital, University of Padua, Via Nicolò Giustiniani 2, 35128, Padua, Italy.
Giacomo CesterDepartment of Neuroradiology, Padua University Hospital, University of Padua, Via Nicolò Giustiniani 2, 35128, Padua, Italy.
Francesco CausinDepartment of Neuroradiology, Padua University Hospital, University of Padua, Via Nicolò Giustiniani 2, 35128, Padua, Italy.
David LiebeskindDepartment of Neurology, Neurovascular Imaging Research Core and UCLA Stroke Center, David Geffen School of Medicine, University of California at Los Angeles, 635 Charles E. Young Drive South, Los Angeles, CA, 90095, USA.
Claudio BaracchiniDepartment of Neurology and Stroke Center, Padua University Hospital, University of Padua, Via Nicolò Giustiniani 2, 35128, Padua, Italy. claudiobaracchini@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Large vessel occlusion (LVO) acute ischemic stroke represents a leading cause of disability despite successful endovascular treatment (EVT). Venous outflow has recently emerged as a potential predictor of functional outcome in ischemic stroke. We aimed to investigate whether a comprehensive venous drainage evaluation is associated with stroke evolution and functional outcome. Prospective study on acute stroke patients with anterior LVO who underwent optimal recanalization from February 2023 to February 2024. Opacification and drainage time of superficial and deep veins were evaluated on digital subtraction angiography sequences. Clinical outcome was functional recovery at 90 days, whereas neuroradiological outcomes were ischemic lesion growth (ILG) and hemorrhagic transformation (HT). Multivariate logistic and linear regression models were performed. 24/50 patients (48%) displayed an unfavorable outcome, 14/50 (28%) a HT, and 28/50 (56%) an ILG. Longer median washout times of the superficial venous system were independently associated with a higher risk of poor functional outcome (aOR = 1.32; 95% CI 1.02-1.79; p = 0.049), ILG (aB = 3.06; SE 1.26; p = 0.020) and HT (aOR = 1.65; 95% CI 1.21-2.47; p = 0.005), and cortical frontal veins were the best predictor within veins' group. Opacification of Labbè and superficial middle cerebral veins predicted only HT (aOR = 0.178; 95% CI 0.026-0.766, p = 0.041) and ILG (aB = 9.78; SE 2.75; p = 0.003), respectively. In this cohort of LVO acute ischemic stroke patients with an optimal recanalization after EVT, qualitative and quantitative aspects of venous outflow were independent predictors of stroke evolution and functional outcome. A comprehensive venous outflow evaluation represents a potential target for a tailored management of patients after EVT.

Indexed as

Cerebral VeinsEndovascular ProceduresIschemic StrokeAgedAged, 80 and overAngiography, Digital SubtractionFemaleHumansMaleMiddle AgedProspective StudiesTreatment OutcomeAcute strokeCerebral veinsEndovascular procedureHemodynamics

Identifiers

PMID40781220

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.