Observational studyJournal of assisted reproduction and genetics2025
Euploidy rate and reproductive outcomes in embryos biopsied at days 5, 6, 7 and 8 of development: a multicenter study.
Observational study in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- ESHRE PGT Consortium data collection XXII-XXIV: PGT analyses from 2019 to 2021†.Human reproduction (Oxford, England) · 2026Article
- Article
- HLA-G, IL-6 and TGF-β in Seminal Plasma as Potential Biomarkers of ART Outcome.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the euploidy rate and obtain the biochemical pregnancy, implantation, clinical pregnancy, miscarriage and live birth rates for embryos biopsied on days 5, 6, 7 and 8 of development.
methodsObservational, retrospective and multicenter study. In total, 1845 IVF‒ICSI cycles with preimplantation genetic testing for aneuploidy (PGT-A) were included. The euploidy rate was determined according to the biopsy day (5, 6, 7 or 8), as were the reproductive outcomes of 710 single embryo transfers (SETs).
resultsSeven thousand three hundred thirty-eight biopsied embryos were analyzed by means of PGT-A. Of these, 414 procedures resulted in amplification failure (5.6%), leaving 6924 embryos. In total, 5042 (72.8%) were biopsied on day 5, 1779 (25.7%) on day 6, 101 (1.5%) on day 7, and 2 (0.03%) on day 8. The euploidy rates on days 5, 6, 7 and 8 were 41.6%, 32.7%, 27.7%, and 50%, respectively. The euploid embryo biopsied on day 8 was not transferred. For blastocysts biopsied on days 5, 6 or 7, the biochemical pregnancy rates were 62.3%, 53.2% and 33.3%; the implantation rates were 59.8%, 50.3% and 22.2%; the clinical pregnancy rates were 59.7%, 42.2% and 22.2%; the live birth rates were 52.5%, 43.2% and 22.2%; and the miscarriage rates were 12.2%, 14.0% and 0%, respectively.
conclusionsThe euploidy rate decreased with increasing time required to reach the blastocyst stage. Compared with day 6 and day 7 euploid embryos, day 5 euploid embryos had better clinical outcomes. However, the findings in this study demonstrate that embryos with slow development can result in live births. CLINICAL
trial registrationDue to being a retrospective study, the clinical trial was not registered.
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