Evidence map›Paper›PMID 40781148›Full record

ArticleScientific reports2025

CB2 and TRPV1 receptors in inflammatory state of macrophages from sickle cell anemia pediatric/young adults.

Giuseppe Di Feo, Giulia Giliberti, Deeksha Rana-Seyfert, Maria Maddalena Marrapodi, Maddalena Casale, Shakeel Ahmed, Silverio Perrotta, Francesca Rossi, Domenico Roberti, Alessandra Di Paola

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giuseppe Di Feo *Department of Woman, Child and General and Specialist Surgery, University of Campania "Luigi Vanvitelli", Napoli, 80138, Italy.
Giulia Giliberti *Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Napoli, 80138, Italy.
Deeksha Rana-SeyfertDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Napoli, 80138, Italy.
Maria Maddalena MarrapodiDepartment of Woman, Child and General and Specialist Surgery, University of Campania "Luigi Vanvitelli", Napoli, 80138, Italy.
Maddalena CasaleDepartment of Woman, Child and General and Specialist Surgery, University of Campania "Luigi Vanvitelli", Napoli, 80138, Italy.
Shakeel AhmedDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Napoli, 80138, Italy.
Silverio PerrottaDepartment of Woman, Child and General and Specialist Surgery, University of Campania "Luigi Vanvitelli", Napoli, 80138, Italy.
Francesca RossiDepartment of Woman, Child and General and Specialist Surgery, University of Campania "Luigi Vanvitelli", Napoli, 80138, Italy. francesca.rossi@unicampania.it.
Domenico RobertiDepartment of Woman, Child and General and Specialist Surgery, University of Campania "Luigi Vanvitelli", Napoli, 80138, Italy.
Alessandra Di PaolaDepartment of Woman, Child and General and Specialist Surgery, University of Campania "Luigi Vanvitelli", Napoli, 80138, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sickle Cell Disease (SCD) is a monogenic disorder characterized by the production of abnormal hemoglobin. Polymerization of HbS causes sickling of red blood cells (RBCs) evidenced by acute adverse events and persistent inflammatory state, vasculopathy and organ damage. Sickled RBCs cause an anemic condition and vaso-occlusive crisis which trigger leukocytes, endothelial cells, and platelets. Due to these events, SCD patients unveiled an elevated level of pro-inflammatory cytokines, which contribute to the ongoing inflammatory state, oxidative stress, and other severe complications. SCD patients also experience neuropathic, inflammatory, and nociceptive pain. The discovery of novel therapeutic approaches and targets to counteract and manage inflammation in SCD are needed. Our study aimed to better understand the role of macrophages in SCD inflammation by first investigating their phenotype and then studying the iron metabolism involvement in the inflammatory processes. Therefore, given the importance to find novel therapeutic approach to contain and manage inflammation in these patients, and considering the role of CB2 and TRPV1 in this process, we decided to investigate the expression of these receptors and the effects of their stimulation on inflammatory state in SCD macrophages.

Indexed as

Anemia, Sickle CellInflammationMacrophagesReceptor, Cannabinoid, CB2TRPV Cation ChannelsAdolescentAdultChildCytokinesFemaleHumansIronMaleYoung AdultCytokinesIronReceptor, Cannabinoid, CB2TRPV1 protein, humanTRPV Cation ChannelsEndocannabinoid/Endovanilloid systemInflammationIron metabolismMacrophage polarizationSickle cell anemia

Identifiers

PMID40781148
PMCPMC12334692

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