Evidence map›Paper›PMID 40780993›Full record

ReviewTrends in genetics : TIG2025

The molecular evolutionary basis of species formation revisited.

Megan E Frayer, Nemo V Robles, María José Rodríguez-Barrera, Jenn M Coughlan, Molly Schumer

Abstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Genetics and genomics of hybridization.Nature reviews. Genetics · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Evolutionary persistence and divergence of thebioRxiv : the preprint server for biology · 2025
    Article
  9. The X chromosome and the emergence of reproductive isolation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Megan E FrayerDepartment of Ecology & Evolutionary Biology, Yale University, New Haven, CT, USA.
Nemo V RoblesDepartment of Biology, Stanford University, Stanford, CA, USA; Centro de Investigaciones Científicas de las Huastecas 'Aguazarca', A.C., Hidalgo, México.
María José Rodríguez-BarreraDepartment of Biology, Stanford University, Stanford, CA, USA; Escuela Nacional de Estudios Superiores Juriquilla, Universidad Nacional Autónoma de México, Querétaro, México.
Jenn M CoughlanDepartment of Ecology & Evolutionary Biology, Yale University, New Haven, CT, USA.
Molly SchumerDepartment of Biology, Stanford University, Stanford, CA, USA; Centro de Investigaciones Científicas de las Huastecas 'Aguazarca', A.C., Hidalgo, México; Freeman Hrabowski Scholar, Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address: schumer@stanford.edu.

Funding

The population genomics of hybridization: from genetic incompatibilities to genome evolutionR35GM133774 · NIGMS · STANFORD UNIVERSITY · PI Molly Schumer · 2019 to 2026
$3.3M
The Evolution of Genomic Imprinting and Strong Reproductive IsolationR35GM150907 · NIGMS · YALE UNIVERSITY · PI Jennifer M. Coughlan · 2023 to 2026
$1.7M
NIGMS NIH HHS R35 GM133774NIGMS NIH HHS R35 GM150907
6 · The paper itself

Abstract

How do new species arise? This is among the most fundamental questions in evolutionary biology. The first genetic model for how reproductive barriers lead to the origin of new species was proposed nearly 90 years ago. However, empirical evidence for the genetic mechanisms that cause reproductive barriers took many decades to accumulate. In 2010, Presgraves presented a comprehensive review of the literature on known 'speciation genes' and the possible evolutionary mechanisms through which they arose. Fifteen years later, with an explosion of studies that include both non-model and model organisms, the number of known hybrid incompatibility genes has increased approximately sevenfold. Here, we synthesize previous and new empirical examples to investigate the genetic mechanisms through which intrinsic incompatibilities in hybrids arise and highlight current gaps in our understanding.

Indexed as

Evolution, MolecularGenetic SpeciationAnimalsBiological EvolutionHybridization, GeneticModels, Geneticgenetic incompatibilityhybridintragenomic conflictintrogressionreproductive isolation

Identifiers

PMID40780993
PMCPMC13095398

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.