Evidence map›Paper›PMID 40780866›Full record

ArticleBJGP open2026

Cardiovascular risk management in patients using antipsychotics: a qualitative feasibility study.

Karlijn Joëlle van den Brule-Barnhoorn, Kirstine Marieke Jakobs, Jan van Lieshout, Sietske Grol, Joost Janzing, Wiepke Cahn, Marion Biermans, Erik Bischoff

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Article in BJGP open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Karlijn Joëlle van den Brule-BarnhoornDepartment of Primary and Community Care, Radboudumc, Nijmegen, Netherlands karlijn.vandenbrule-barnhoorn@radboudumc.nl.ORCID https://orcid.org/0000-0002-4441-5430
Kirstine Marieke JakobsDepartment of Primary and Community Care, Radboudumc, Nijmegen, Netherlands.ORCID https://orcid.org/0000-0001-9464-1607
Jan van LieshoutIQ Health Science Department, Radboudumc, Nijmegen, Netherlands.ORCID https://orcid.org/0000-0001-8895-7349
Sietske GrolDepartment of Primary and Community Care, Radboudumc, Nijmegen, Netherlands.ORCID https://orcid.org/0000-0002-9917-6932
Joost JanzingDepartment of Psychiatry, Radboudumc, Nijmegen, Netherlands.ORCID https://orcid.org/0000-0002-8409-7473
Wiepke CahnDepartment of Psychiatry, UMC Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-0482-8759
Marion BiermansDepartment of Primary and Community Care, Radboudumc, Nijmegen, Netherlands.ORCID https://orcid.org/0000-0001-5401-3817
Erik BischoffDepartment of Primary and Community Care, Radboudumc, Nijmegen, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients on antipsychotic medication (APM) have an increased risk of cardiovascular disease (CVD). In general practice, however, there is a lack of solid cardiovascular risk (CVR) management for this specific group. TACTIC, a person-centred multidisciplinary cardiovascular risk programme, which aims to decrease cardiovascular risk and review APM use, was piloted in general practice.

aimTo explore barriers and facilitators for delivering the TACTIC intervention, and assess which adjustments have to be made to evaluate its effectiveness and implementability in a future randomised controlled trial (RCT). DESIGN &

settingQualitative analysis of the feasibility study in three Dutch general practices.

methodWe performed eight individual interviews with patients and two focus group interviews with 11 healthcare professionals (HCPs) involved in the study. Interviews were semi-structured and topic guides were informed by the normalisation process theory (NPT). We used the framework method for analysis of our data.

resultsThe three main barriers for delivering TACTIC were as follows: the tension towards the intervention experienced by patients; the course of the multidisciplinary meeting (MDM); and the high workload experienced by GPs. The main facilitators were associated with the person-centred approach, the clear information meeting, and the ability of adjusting roles during the course of the intervention, including bringing a carer. Valuable suggestions for improvement were introducing a summary report from the psychiatrist, improving expectation management for patients, and adjusting the definition of the target group.

conclusionSeveral adjustments to the TACTIC intervention are necessary before evaluation in a larger RCT can take place. This work underlines the importance of performing a feasibility study before a trial to improve its effectiveness and efficacy.

Indexed as

antipsychotic agentsfeasibilityheart diseasesmedication review

Identifiers

PMID40780866
PMCPMC13540358

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.