Evidence map›Paper›PMID 40780497›Full record

ArticleThe Journal of nutrition2025

Dietary Intake of Animal and Plant Proteins and Risk of Gastrointestinal Cancer Mortality: Results from the Golestan Cohort Study.

Farideh Shiraseb, Abbasali Keshtkar, Hossein Poustchi, Akram Pourshams, Arash Etemadi, Farin Kamangar, Paolo Boffetta, Christian C Abnet, Khadijeh Mirzaei, Reza Malekzadeh and 1 more

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Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Farideh ShirasebDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Abbasali KeshtkarDepartment of Disaster and Emergency Health, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Hossein PoustchiLiver and Pancreaticobiliary Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Akram PourshamsLiver and Pancreaticobiliary Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Arash EtemadiMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Farin KamangarDepartment of Biology, School of Computer, Mathematical, and Natural Sciences, Morgan State University, Baltimore, MD, United States.
Paolo BoffettaDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Stony Brook Cancer Center, Stony Brooke University, Stony Brook, NY, United States.
Christian C AbnetMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Khadijeh MirzaeiDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: mirzaei_kh@sina.tums.ac.ir.
Reza MalekzadehDigestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Maryam HashemianHeart Disease Phenomics Laboratory, Epidemiology and Community Health Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address: maryam.hashemian2@nih.gov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastrointestinal (GI) cancers account for a significant global cancer burden, but the link between intake of proteins from different sources and GI cancer mortality is unclear.

objectivesThis study examined associations between the percentage of energy received from animal protein intake (API) and plant protein intake (PPI), and mortality from esophageal (EC), gastric (GC), colorectal (CRC), and pancreatic (PC) cancers in 42,323 participants of the Golestan Cohort Study (GCS).

methodsUsing data from a baseline food frequency questionnaire, hazard ratios (HRs) were estimated through Cox models, including isocaloric substitution analyses of API and PPI.

resultsDuring 13.4 y of follow-up, 676 deaths from GI cancer occurred. We found no association between API and GI cancer mortality [HR

conclusionsIn the GCS, with refined grains as the main source of PPI, we observed a positive association between PPI and GI cancer and EC mortality. Future studies should focus on food groups simultaneously.

Indexed as

Animal Proteins, DietaryDietDietary ProteinsGastrointestinal NeoplasmsPlant ProteinsAdultAgedCohort StudiesFemaleHumansIranMaleMiddle AgedProportional Hazards ModelsRisk FactorsSurveys and QuestionnairesAnimal Proteins, DietaryDietary ProteinsPlant Proteinsanimal proteingastrointestinal cancerisocaloric substitutionplant protein

Identifiers

PMID40780497
PMCPMC12612602

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.