ArticleInternational journal of biological macromolecules2025
Comprehensive biophysical and biochemical characterization of polymerized dopamine coated hemoglobin based oxygen carrier.
Article in International journal of biological macromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Hemoglobin-based oxygen carriers with antioxidant properties.Journal of materials chemistry. B · 2026Article
- Biophysical and Biochemical Characterization of High Molecular Weight Co-Polymerized Human Hemoglobin and Albumin as a Potential Hemoglobin-Based Oxygen Carrier.ACS biomaterials science & engineering · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Hemoglobin (Hb)-based oxygen carriers (HBOCs) are promising red blood cell (RBC) substitutes, when blood is unavailable. However, HBOCs can generate reactive oxygen species (ROS) species leading to oxidative stress, lipid peroxidation, DNA damage, and cell death. To address these issues, researchers have explored coating Hb and HBOCs with polymerized dopamine (PDA), to impart antioxidant properties via radical scavenging. This study builds upon previous PDA-coated Hb (PDA-hHb-1) research by quantifying HBOC biophysical properties and proposing two new PDA coating methods: 1) first binding carbon monoxide (CO) to human Hb (hHb) prior to PDA-coating to reduce metHb formation (PDA-hHb-13), and 2) forming PDA nanoparticles (NPs) before coating them with HbCO (PDA-hHb-15). After CO removal, PDA-hHb-13 and PDA-hHb-15 exhibited lower metHb levels (< 10 %) compared to PDA-hHb-1 (∼13 %). PDA-hHb-15 had a reduced auto-oxidation rate constant compared to PDA-hHb-13, though both exceeded the precursor hHb. Functionally, PDA-coated hHbs retained similar oxygen offloading kinetics, with PDA-hHb-13 showing a lower oxygen affinity. PDA-coated hHbs exhibited enhanced ferric reducing and radical scavenging activity, but also increased ferryl species formation in the presence of H
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.