Evidence map›Paper›PMID 40780145›Full record

ArticleHealth & place2025

Living in a 20-min neighborhood and brain health and resilience in older adults: The Healthy Brain Initiative.

Lilah M Besser, Elaine Le, Madeleine Tourelle, Deirdre M O'Shea, Diana Mitsova, James E Galvin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Health & place, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lilah M BesserComprehensive Center for Brain Health, Department of Neurology, University of Miami, 7700 W Camino Real, Suite 200, Boca Raton, FL, 33433, USA. Electronic address: lmb9767@miami.edu.
Elaine LeComprehensive Center for Brain Health, Department of Neurology, University of Miami, 7700 W Camino Real, Suite 200, Boca Raton, FL, 33433, USA.
Madeleine TourelleComprehensive Center for Brain Health, Department of Neurology, University of Miami, 7700 W Camino Real, Suite 200, Boca Raton, FL, 33433, USA.
Deirdre M O'SheaComprehensive Center for Brain Health, Department of Neurology, University of Miami, 7700 W Camino Real, Suite 200, Boca Raton, FL, 33433, USA.
Diana MitsovaDepartment of Urban and Regional Planning, Florida Atlantic University, 777 Glades Road, SO-273, Boca Raton, FL, 33431, USA.
James E GalvinComprehensive Center for Brain Health, Department of Neurology, University of Miami, 7700 W Camino Real, Suite 200, Boca Raton, FL, 33433, USA.

Funding

Multicultural Community Dementia ScreeningR01AG071514 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALVIN, JAMES E · 2021 to 2025
$13.8M
Reducing Disparities in Dementia and VCID Outcomes in a Multicultural Rural PopulationR01NS101483 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALVIN, JAMES E · 2019 to 2023
$8.0M
The effects of Alzheimer's disease risk genes on metabolism and signaling across cell typesRF1AG075901 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FRAENKEL, ERNEST, TSAI, LI-HUEI · 2022 to 2025
$6.5M
Deep Phenotypic Characterization of Prodromal Dementia with Lewy BodiesR56AG074889 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALVIN, JAMES E · 2022 to 2022
$3.2M
Longitudinal associations between neighborhood greenspace and brain aging in cognitively normal older adultsK01AG063895 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BESSER, LILAH · 2020 to 2024
$628k
NIA NIH HHS K01 AG063895NIA NIH HHS R01 AG071514NIA NIH HHS R56 AG074889NIA NIH HHS RF1 AG075901NIH HHS R01AG071514S1NIH HHS R01NS101483S1NINDS NIH HHS R01 NS101483
6 · The paper itself

Abstract

The 20-min neighborhood (20 MN) concept, aimed at fostering livable communities, has garnered increasing attention among urban planners and policy makers. 20 MNs provide most daily needs (e.g., grocery, parks) within a 20-min walk of home. Among 352 older adults in the Healthy Brain Initiative (HBI), we examined whether 20 MN measures were associated with resilience against future cognitive impairment/dementia measured via the Resilience Index (RI), as well as with structural magnetic resonance imaging measures (i.e., hippocampal volume, white matter hyperintensity (WMH) volume). We calculated density of destinations within a 20-min walk of home across seven domains (i.e., social destinations, dining places, shopping/retail, grocery/supermarkets, healthcare facilities, parks, and transit availability) and created a dichotomous 20 MN variable (≥1 destination within a 20-min walk in all seven domains, yes versus no). In multivariable linear regression analyses, greater density of parks, greater density of grocery/supermarkets, and living in a 20 MN were associated lower WMH volumes. Our study suggests brain health benefits for older adults with greater densities of grocery and park destinations within a 20-min walk of home, as well as those living in 20 MNs. Future studies corroborating our findings for beneficial associations between 20 MNs and brain health would provide significant policy implications for dementia prevention.

Indexed as

BrainNeighborhood CharacteristicsResidence CharacteristicsResilience, PsychologicalAgedAged, 80 and overCognitive DysfunctionDementiaFemaleHumansMagnetic Resonance ImagingMaleWalking20-Min neighborhoodBrain healthBrain resilienceGreenspaceMagnetic resonance imagingWalking destinations

Identifiers

PMID40780145
PMCPMC12433669

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.