Evidence map›Paper›PMID 40780053›Full record

ArticleStructure (London, England : 1993)2025

Dynamic intraligand binding reveals a new function for PDZ domains.

Ernesto J Fuentes

Abstract readComment
In one paragraph

Article in Structure (London, England : 1993), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Ernesto J FuentesDepartment of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA 52242, USA. Electronic address: ernesto-fuentes@uiowa.edu.

Funding

Molecular Mechanisms Regulating Bacterial Two-component Signaling SystemsR01AI170557 · NIAID · UNIVERSITY OF IOWA · PI Ernesto Jorge Fuentes · 2023 to 2026
$2.3M
NIAID NIH HHS R01 AI170557
6 · The paper itself

Abstract

PDZ (PSD-95/Discs-large/ZO-1) domains canonically interact with the C termini of partner proteins; however, they also bind internal motifs. In this issue of Structure, Kumar et al.

Indexed as

PDZ DomainsBinding SitesDisks Large Homolog 4 ProteinHumansLigandsProtein BindingDisks Large Homolog 4 ProteinLigands

Identifiers

PMID40780053
PMCPMC12784222

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.