Evidence map›Paper›PMID 40779943›Full record

ArticleEnvironment international2025

Personal care product use and risk of adult-onset asthma: Prospective cohort analyses of U.S. Women from the Sister Study.

Jungeun Lim, Che-Jung Chang, Alexandra J White, Shelton Lo, Hantao Wang, Gabriel A Goodney, Rui Miao, Amisha V Barochia, Véronique L Roger, Dale P Sandler and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jungeun LimEpidemiology and Community Health Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
Che-Jung ChangEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Alexandra J WhiteEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Shelton LoEpidemiology and Community Health Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
Hantao WangEpidemiology and Community Health Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
Gabriel A GoodneyEpidemiology and Community Health Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
Rui MiaoOffice of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
Amisha V BarochiaPulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Véronique L RogerEpidemiology and Community Health Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Jason Y Y WongEpidemiology and Community Health Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA. Electronic address: jason.wong@nih.gov.

Funding

Biological mechanisms underlying the relationships between environmental exposures and risk of respiratory and cardiovascular diseasesZIAHL006285 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI WONG, JASON · 2023 to 2025
$3.8M
Genetic and Environmental Risk Factors for Breast Cancer: The Sister StudyZ01ES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 1999 to 2008
$1.3M
Intramural NIH HHS Z01 ES044005Intramural NIH HHS ZIA HL006285
6 · The paper itself

Abstract

backgroundPopulation studies have found associations between prenatal exposure to endocrine-disrupting chemicals (EDCs) in personal care products (PCPs) and childhood asthma; however, few have examined adult-onset asthma. We investigated the associations between commonly used PCPs and the risk of adult-onset asthma in a prospective cohort study of U.S. women.

methodsWe analyzed 39,408 participants from the Sister Study who self-reported their usage frequency of 41 PCPs in the 12-month period before baseline (2003-2009). In our combined PCP analyses, we used Least Absolute Shrinkage and Selection Operator (LASSO) to select key PCPs that predict the risk of adult-onset asthma. In group-specific analyses, PCPs were aggregated into four product groups (i.e., beauty, everyday hair, hygiene, and skincare products). Subsequently, we conducted latent class analysis to identify groups of participants with similar patterns of PCP use (e.g., infrequent (reference), moderate, and frequent). Multivariable Cox regression models were used to assess the associations between PCP use and incident adult-onset asthma.

resultsOver an average 12.5-year follow-up, 1,774 incident asthma cases were identified. We found a positive association between combined PCP use and adult-onset asthma risk (moderate users, hazard ratio [HR] = 1.19 (95% confidence interval (CI):1.05,1.33) and frequent users, HR = 1.19 (95% CI:1.06,1.34)). In group-specific analyses, moderate (HR = 1.21 (95% CI:1.07,1.37)) and frequent (HR = 1.22 (95% CI:1.08,1.38)) users of beauty products had higher asthma risk compared to infrequent users. Similar associations were observed for hygiene (moderate: HR = 1.14 (95% CI:1.01,1.29) and frequent: HR = 1.20 (95% CI:1.06,1.36)) and skincare products (moderate: HR = 1.21 (95% CI:1.06,1.38) and frequent: HR = 1.20 (95% CI:1.06,1.35)).

conclusionsOur findings suggest that PCP use potentially contributes to future risk of adult-onset asthma among women.

Indexed as

AsthmaCosmeticsEndocrine DisruptorsEnvironmental ExposureAdultFemaleHumansMiddle AgedProspective StudiesUnited StatesCosmeticsEndocrine DisruptorsAsthmaEndocrine disruptorsPersonal care productsProspective cohort study

Identifiers

PMID40779943
PMCPMC12365912

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.