Evidence map›Paper›PMID 40779636›Full record

ArticleScience advances2025

Digital light processing of photoresponsive and programmable hydrogels.

Abhishek P Dhand, Bruce E Kirkpatrick, Manuela Garay-Sarmiento, Benjamin R Nelson, Connor E Miksch, Bianca Meurer-Zeman, Hannah M Zlotnick, Arkodip Mandal, Joshua S Lee, Jaxon Cione and 3 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. γ-Ray Regulated Host-Guest Molecular Recognition.Angewandte Chemie (International ed. in English) · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Abhishek P DhandDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-1470-1081
Bruce E KirkpatrickDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.ORCID 0000-0003-2862-3843
Manuela Garay-SarmientoDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.ORCID 0000-0003-3821-1340
Benjamin R NelsonDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.ORCID 0000-0002-6702-079X
Connor E MikschDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.ORCID 0000-0003-0082-4862
Bianca Meurer-ZemanDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.
Hannah M ZlotnickDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.ORCID 0000-0002-0942-3072
Arkodip MandalDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.ORCID 0000-0002-0488-1816
Joshua S LeeDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.ORCID 0009-0005-3542-8909
Jaxon CioneDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.ORCID 0009-0002-1862-9598
Christopher N BowmanDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.ORCID 0000-0001-8458-7723
Kristi S AnsethDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.ORCID 0000-0002-5725-5691
Jason A BurdickDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-2006-332X

Funding

Osteogenic Hydrogel Niches to Promote hMSC Migration and DifferentiationR01DE016523 · NIDCR · UNIVERSITY OF COLORADO AT BOULDER · PI ANSETH, KRISTI S. · 2005 to 2023
$6.2M
Synthetic hydrogels to study formation and maintenance of intestinal cryptsR01DK120921 · NIDDK · UNIVERSITY OF COLORADO · PI KRISTI S. ANSETH, PETER J DEMPSEY · 2019 to 2026
$3.8M
Engineered Granular Hydrogels for Endogenous Tissue RepairR01HL160616 · NHLBI · UNIVERSITY OF COLORADO · PI BURDICK, JASON A · 2022 to 2025
$2.5M
Engineered Developmental Microenvironments: Cartilage Formation and MaturationR01AR077362 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI BURDICK, JASON A, MAUCK, ROBERT L · 2020 to 2024
$2.5M
Interdisciplinary Training in Musculoskeletal ResearchT32AR080630 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Karin A Payne, MICHAEL J ZUSCIK · 2022 to 2026
$1.7M
Biofabrication Training ProgramT32EB034215 · NIBIB · UNIVERSITY OF COLORADO · PI Stephanie J Bryant, Jason A Burdick · 2024 to 2026
$512k
NHLBI NIH HHS R01 HL160616NIAMS NIH HHS R01 AR077362NIAMS NIH HHS T32 AR080630NIBIB NIH HHS T32 EB034215NIDCR NIH HHS R01 DE016523NIDDK NIH HHS R01 DK120921
6 · The paper itself

Abstract

Light-mediated manipulation of hydrogel physicochemical properties is attractive for numerous applications, yet the processing of such hydrogels via vat photopolymerization [e.g., digital light processing (DLP)] is challenging as photoresponsive chemistries may be consumed during printing. Here, we report a facile strategy to DLP print hydrogels that combines short light exposures to set the shape of a printed object and complementary dark polymerization to continue the reaction of macromers without disturbing photoresponsive groups. Postprinting, hydrogels are then programmed using single- or multiphoton light and photoinitiator-free reactions: tetrazole-alkene click reaction (for photofunctionalization), dithiolane ring-opening polymerization (for photostiffening), and

Identifiers

PMID40779636
PMCPMC12333685

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.