Evidence map›Paper›PMID 40779632›Full record

ArticleScience advances2025

A human NK cell progenitor that originates in the thymus and generates KIR

Julian Reiß, Sujal Ghosh, Michael Scheid, Lea Graafen, Nadine Scherenschlich, Sandra Weinhold, Katharina Raba, Stefan Paulusch, Elena De Dominico, Thi X U Pham and 6 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Julian ReißInstitute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstr. 5, Düsseldorf, Germany.ORCID 0009-0002-2540-5736
Sujal GhoshDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, Germany.ORCID 0000-0001-5647-4262
Michael ScheidHerzzentrum Duisburg, Evangelisches Klinikum Niederrhein, Gerrickstraße 21, Duisburg, Germany.
Lea GraafenDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, Germany.
Nadine ScherenschlichInstitute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstr. 5, Düsseldorf, Germany.ORCID 0009-0001-0361-6375
Sandra WeinholdInstitute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstr. 5, Düsseldorf, Germany.ORCID 0000-0002-0725-4199
Katharina RabaInstitute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstr. 5, Düsseldorf, Germany.ORCID 0000-0001-8818-4219
Stefan PauluschPRECISE Platform for Genomics and Epigenomics at German Center for Neurodegenerative Diseases (DZNE) and University of Bonn and West German Genome Center, Bonn, Germany.
Elena De DominicoPRECISE Platform for Genomics and Epigenomics at German Center for Neurodegenerative Diseases (DZNE) and University of Bonn and West German Genome Center, Bonn, Germany.ORCID 0000-0003-0336-8284
Thi X U PhamInstitute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstr. 5, Düsseldorf, Germany.
Marc BeyerPRECISE Platform for Genomics and Epigenomics at German Center for Neurodegenerative Diseases (DZNE) and University of Bonn and West German Genome Center, Bonn, Germany.ORCID 0000-0001-9704-148X
Hans-Jürgen LawsDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, Germany.
Tim NiehuesDepartment of Pediatrics, Helios Klinikum Krefeld, Krefeld, Germany.ORCID 0000-0002-9945-8833
Arndt BorkhardtDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, Germany.
Markus UhrbergInstitute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstr. 5, Düsseldorf, Germany.ORCID 0000-0001-9553-1987
Sabrina B BennsteinInstitute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstr. 5, Düsseldorf, Germany.ORCID 0000-0003-0477-2748

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

KIR

Indexed as

Killer Cells, NaturalNK Cell Lectin-Like Receptor Subfamily CReceptors, KIRThymus GlandCell DifferentiationHumansKLRC1 protein, humanNK Cell Lectin-Like Receptor Subfamily CReceptors, KIR

Identifiers

PMID40779632
PMCPMC12333686

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.