Evidence map›Paper›PMID 40779593›Full record

ArticlePloS one2025

Proximal and distal middle cerebral artery diameter ratio and lenticulostriate artery infarction.

Jun Sang Yoo, Jae Hyun Choi, Jae Young Park, Jeong Yun Song, Jun Young Chang, Dong-Wha Kang, Sun U Kwon, Hang Jin Jo, Bum Joon Kim

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Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jun Sang YooDepartment of Neurology, Asan Medical Center, University of Ulsan, Seoul, South Korea.ORCID https://orcid.org/0000-0003-2033-1002
Jae Hyun ChoiDepartment of Mechanical engineering, POSTECH, Pohang, South Korea.
Jae Young ParkDepartment of Neurology, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Jeong Yun SongDepartment of Neurology, Asan Medical Center, University of Ulsan, Seoul, South Korea.ORCID https://orcid.org/0000-0003-4992-1065
Jun Young ChangDepartment of Neurology, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Dong-Wha KangDepartment of Neurology, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Sun U KwonDepartment of Neurology, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Hang Jin JoDepartment of Mechanical engineering, POSTECH, Pohang, South Korea.
Bum Joon KimDepartment of Neurology, Asan Medical Center, University of Ulsan, Seoul, South Korea.ORCID https://orcid.org/0000-0002-3278-3252

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLipohyalinotic degeneration (LD) and branch atheromatous disease (BAD) can contribute to subcortical infarctions in the lenticulostriate artery (LSA) territory. This study aimed to identify the association between the proximal and distal middle cerebral artery (MCA) diameter ratio and the two different pathomechanisms of LSA infarction.

methodsPatients with acute LSA infarctions categorized as small vessel occlusive disease were included. Demographic and clinical data, along with MCA geometrical variables, were collected. LD and BAD were differentiated based on the length of the infarction diameter and number of axial slices. The proximal/distal M1 diameter ratio was calculated. MCA geometrics between LD and BAD were compared. Independent factors associated with LD were investigated. Computational fluid dynamics (CFD) analysis was used to evaluate hemodynamic parameters.

resultsA total of 117 patients were included, of whom 64 (54.7%) and 53 (45.3%) were classified as BAD and LD, respectively. LD was associated with hypertension and favorable prognosis. MCA geometric variables revealed that LD had a higher proximal/distal M1 diameter ratio, indicating a potential distinguishing factor. Multivariate analysis confirmed the independent association between LD and the proximal/distal M1 diameter ratio. The proximal/distal M1 diameter ratio also showed a positive correlation with the number of ipsilesional lacunes. CFD analysis showed that the LD model had faster, greater blood influx into LSAs and higher wall shear stress and pressure gradient compared with the BAD model.

conclusionsThis study suggests MCA geometry, particularly the proximal/distal M1 diameter ratio, may serve as an independent factor for identifying LD.

Indexed as

Basal Ganglia Cerebrovascular DiseaseInfarction, Middle Cerebral ArteryMiddle Cerebral ArteryAgedFemaleHumansMaleMiddle Aged

Identifiers

PMID40779593
PMCPMC12334049

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