Evidence map›Paper›PMID 40779433›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Longitudinal diffusion tensor imaging correlates with amyloid burden in Down syndrome.

Lisette Gwendolyn LeMerise, José Guerrero-Gonzalez, Andrew McVea, Matthew Zammit, Steven Kecskemeti, Sigan Hartley, Elizabeth Head, Mark Mapstone, Benjamin Handen, Andrew Alexander and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Longitudinal diffusion tensor imaging correlates with amyloid burden in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lisette Gwendolyn LeMeriseWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0009-0001-4443-0673
José Guerrero-GonzalezWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Andrew McVeaWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Matthew ZammitWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Steven KecskemetiWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Sigan HartleyWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Elizabeth HeadDepartment of Pathology and Laboratory Medicine, University of California, Irvine, California, USA.
Mark MapstoneDepartment of Neurology, School of medicine, University of California, Irvine, California, USA.
Benjamin HandenDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Andrew AlexanderWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Bradley ChristianWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
ABC‐DS Investigators

Funding

Project 3: Biomarkers for DS Clinical TrialsU19AG068054 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTIAN, BRADLEY T, HANDEN, BENJAMIN L · 2020 to 2025
$103.7M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SWEET, ROBERT A · 1985 to 2019
$43.0M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sanjay Asthana · 2019 to 2026
$34.5M
NiAD Supplement WashU Start UpU01AG051406 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANDEN, BENJAMIN L, TOGA, ARTHUR W · 2015 to 2019
$21.3M
Roles of Gray Matter Brain Aging and Small Vessel Disease in AD PathophysiologyRF1AG025516 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENSTEIN, HOWARD J, VILLEMAGNE, VICTOR LUIS · 2014 to 2021
$9.0M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5M
Natural History of Amyloid Deposition in Adults with Down SyndromeR01AG031110 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANDEN, BENJAMIN L · 2009 to 2016
$5.2M
NIA NIH HHS P30 AG062715NIA NIH HHS P50 AG005133NIA NIH HHS R01 AG031110NIA NIH HHS RF1 AG025516NIA NIH HHS U01 AG051406NIA NIH HHS U19 AG068054NICHD NIH HHS P50 HD105353
6 · The paper itself

Abstract

introductionAdults with Down syndrome (DS) accumulate amyloid beta (Aβ) plaques faster and earlier on average than neurotypical adults with sporadic Alzheimer's disease (AD). White matter (WM) microstructure characterized with diffusion tensor imaging (DTI) can indicate underlying architectural changes in longitudinal studies, suggestive of neurodegeneration. This study investigated relationships between DTI and Aβ in DS along the AD continuum.

methodsUsing longitudinal amyloid Pittsburgh compound B positron emission tomography, Centiloid (CL) and DTI parameters were examined in 35 adults with DS ages 25 to 57. DTI measures of anisotropy and diffusivity were analyzed using tract-based spatial statistics and permutation analysis of linear models, testing for significant correlation between the rates of change for CL and DTI.

resultsAll rates of DTI and Aβ changes were significantly related. Significant regions included the corpus callosum, corona radiata, and long-association fibers. DISCUSSION: Aβ burden is associated with widespread longitudinal WM changes in DS. This suggests WM microstructure alterations accompany amyloid accumulation. HIGHLIGHTS: A Down syndrome-specific template was created. Longitudinal diffusion tensor imaging (DTI) and amyloid burden rates of change correlate. Longitudinal results show more significant regions than cross-sectional results. DTI and amyloid changes were found over two timepoints, 3.7 years apart on average. DTI and amyloid-PET offer greater sensitivity when tracking microstructural changes.

Indexed as

Amyloid beta-PeptidesBrainDiffusion Tensor ImagingDown SyndromePlaque, AmyloidWhite MatterAdultAniline CompoundsFemaleHumansLongitudinal StudiesMaleMiddle AgedPositron-Emission TomographyThiazoles2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazoleAmyloid beta-PeptidesAniline CompoundsThiazolesAlzheimer's diseaseamyloid burdenamyloid positron emission tomographydiffusion magnetic resonance imagingdiffusion tensor imagingDown syndromelinear modelinglongitudinalmultimodalrate of changetract‐based spatial statistics

Identifiers

PMID40779433
PMCPMC12333877

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