Evidence map›Paper›PMID 40779423›Full record

Trial reportJournal of neurotrauma2025

Traumatic Brain Injury Severity Measured by Clinical, Radiographical, and Blood Biomarker Measures Is Associated with Non-Neurological Organ Dysfunction: A Secondary Analysis of ProTECT III and Bio-ProTECT.

David J Barton, Erica K Fan, Ian G Gober, Nabil Awan, Raj G Kumar, Jenna C Carlson, Michael R Frankel, David W Wright, Amy K Wagner

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurotrauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David J BartonDepartment of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-0976-0383
Erica K FanDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ian G GoberDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nabil AwanDepartment of Statistics, University of Wisconsin, Madison, Wisconsin, USA.
Raj G KumarDepartment of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-0858-3533
Jenna C CarlsonDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Michael R FrankelMarcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, Georgia, USA.
David W WrightDepartment of Emergency Medicine, Emory University, Atlanta, Georgia, USA.ORCID 0000-0002-7145-9105
Amy K WagnerDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

ProTECT IIIU01NS062778 · NINDS · EMORY UNIVERSITY · PI WRIGHT, DAVID W · 2009 to 2013
$26.4M
Emergency Medicine Research TrainingT32HL134615 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Clifton W. Callaway, DONALD M YEALY · 2017 to 2026
$2.4M
Biomarkers of Injury and Outcome in Pro-TECT III (BIO-ProTECT)R01NS071867 · NINDS · EMORY UNIVERSITY · PI FRANKEL, MICHAEL ROSS · 2011 to 2015
$1.9M
Predictive Biomarkers & Models Assessing Systemic Response to Injury after Moderate-to-Severe TBIR21NS111063 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WAGNER, AMY K · 2020 to 2020
$444k
NHLBI NIH HHS T32 HL134615NINDS NIH HHS R01 NS071867NINDS NIH HHS R21 NS111063NINDS NIH HHS U01 NS062778
6 · The paper itself

Abstract

Non-neurological organ dysfunction (NNOD) is a prevalent complication and contributes to poor outcome after traumatic brain injury (TBI). Contributing factors to NNOD may include initial TBI severity, but this relationship has not been rigorously studied. The objectives of this study were to describe the frequency and timing of NNOD after TBI, evaluate the association between NNOD and outcome (mortality and Glasgow Outcome Score-Extended [GOSE] at 6 months post-injury), and examine the relationship between multimodal markers of initial TBI severity and NNOD. We performed a secondary analysis of data from participants in both the ProTECT III clinical trial (progesterone vs. placebo in participants with moderate-to-severe TBI) and the embedded Bio-ProTECT blood biomarker study (

Indexed as

Brain Injuries, TraumaticMultiple Organ FailureAdultAgedBiomarkersFemaleGlasgow Outcome ScaleHumansMaleMiddle AgedYoung AdultBiomarkersbiomarkersnon-neurological organ dysfunctionoutcometraumatic brain injury

Identifiers

PMID40779423
PMCPMC13007255

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.