Evidence map›Paper›PMID 40779417›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Cognitive and brain health in women with early bilateral salpingo-oophorectomy: Implications for risk, resilience, and subjective cognitive decline.

Noelia Calvo, Laura Gravelsins, Alana Brown, Sophia Zhao, Nicole Gervais, Annie Duchesne, Shreeyaa Ramana, Laurice Karkaby, Zhuo Shao, Marcus Q Bernardini and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Noelia CalvoDepartment of Psychology, University of Toronto, Toronto, Ontario, Canada.
Laura GravelsinsDepartment of Psychology, University of Toronto, Toronto, Ontario, Canada.
Alana BrownDepartment of Psychology, University of Toronto, Toronto, Ontario, Canada.
Sophia ZhaoDepartment of Psychology, University of Toronto, Toronto, Ontario, Canada.
Nicole GervaisDepartment of Psychology, University of Toronto, Toronto, Ontario, Canada.
Annie DuchesneDepartment of Psychology, University of Northern British Columbia, Prince George, British Columbia, Canada.
Shreeyaa RamanaDepartment of Psychology, University of Toronto, Toronto, Ontario, Canada.
Laurice KarkabyDepartment of Psychology, University of Toronto, Toronto, Ontario, Canada.
Zhuo ShaoGenetics Program, North York General Hospital, Toronto, Ontario, Canada.
Marcus Q BernardiniDivision Head, Gynecologic Oncology, University Health Network, Toronto, Ontario, Canada.
Michelle JacobsonDepartment of Gynecology, Women's College Research Institute, Toronto, Ontario, Canada.
Natasha RajahDepartment of Psychology, Toronto Metropolitan University, Toronto, Ontario, Canada.
Cheryl GradyDepartment of Psychology, University of Toronto, Toronto, Ontario, Canada.
Elizabeth HampsonDepartment of Psychology, University of Western Ontario, London, Ontario, Canada.
Gillian EinsteinDepartment of Psychology, University of Toronto, Toronto, Ontario, Canada.

Funding

Canadian Cancer Society 310336Canadian Consortium on Neurodegeneration in Aging (CCNA) Phase II 163902Canadian Consortium on Neurodegeneration in Aging (CCNA) Phase II CCNA 049-04Canadian Institutes of Health Research (CIHR), Ontario Brain Institute and The Centre for Aging+ Brain Health Innovation (CABHI) WJP-150643Jacqueline Ford Gender and Health FundWilfred and Joyce Posluns Chair in Women's Brain Health and Aging from the Posluns Family Foundation
6 · The paper itself

Abstract

introductionEarly life bilateral salpingo-oophorectomy (BSO) leads to immediate estradiol loss and increased risk of late-life Alzheimer's disease (AD). We investigated risk and resilience (RandR) on the average of 5 years post BSO and their possible impact on subjective cognitive decline (SCD), and brain structure.

methodsA cohort in Canada (n = 333) included women with and without BSO of whom some reported SCD. We used multiple factor analysis, logistic regression, and magnetic resonance imaging to assess RandR, odds of SCD, and differences in gray matter volume (GMV).

resultsBSO was a risk for worse neuropsychological performance, a 2-fold increase in the odds of SCD, and decreases in GMV in regions sensitive to estradiol, and important for mood, memory, and language. However, estradiol therapy (ET DISCUSSION: Risk of SCD exists for younger women with BSO, which affects GMV. Importantly, ET HIGHLIGHTS: Oophorectomy in early middle age may be a risk for subjective cognitive decline. Oophorectomy is associated with less gray matter volume in the prefrontal cortex. Estradiol therapy and verbal IQ might be resilience factors mitigating such risk.

Indexed as

BrainCognitionCognitive DysfunctionResilience, PsychologicalSalpingo-oophorectomyAgedCanadaCohort StudiesEstradiolFemaleGray MatterHumansMagnetic Resonance ImagingMiddle AgedNeuropsychological TestsRisk FactorsEstradiolearly life bilateral salpingo‐oophorectomyestradiolestradiol therapyrisk and resiliencesubjective cognitive declineverbal IQ

Identifiers

PMID40779417
PMCPMC12333622

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.