Evidence map›Paper›PMID 40779386›Full record

ArticleIEEE transactions on bio-medical engineering2026

ProBot: Robot-Ultrasound Probe for Transrectal and Transperineal Prostate Biopsy.

Dan Stoianovici, Sunghwan Lim, Kunio Hashiba, John Waddell, Doru Petrisor, Jakub Piwowarczyk, Arvin K George, Katarzyna J Macura, Misop Han

Abstract read
In one paragraph

Article in IEEE transactions on bio-medical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dan Stoianovici
Sunghwan Lim
Kunio Hashiba
John Waddell
Doru Petrisor
Jakub Piwowarczyk
Arvin K George
Katarzyna J Macura
Misop Han

Funding

Robot-Assisted Personalized Prostate BiopsyR01CA247959 · NCI · JOHNS HOPKINS UNIVERSITY · PI STOIANOVICI, DAN · 2021 to 2025
$1.5M
A New Ultrasound Probe and Robot for Prostate Biopsy and Focal TherapyR01CA303859 · NCI · JOHNS HOPKINS UNIVERSITY · PI DAN STOIANOVICI · 2025 to 2026
$1.0M
Ultrasound-Guided Navigation in Robot-Assisted Laparoscopic Radical ProstatectomyR21CA141835 · NCI · JOHNS HOPKINS UNIVERSITY · PI HAN, MISOP, STOIANOVICI, DAN · 2009 to 2010
$554k
NCI NIH HHS R01 CA247959NCI NIH HHS R01 CA303859NCI NIH HHS R21 CA141835
6 · The paper itself

Abstract

objectiveOver the past decade the incidence of prostate cancer (PCa) has been on a steady increase. Efforts to improve PCa outcome include targeted biopsy with magnetic resonance imaging (MRI) and precision sampling. Several biopsy devices are currently available to guide the biopsy with MRI-ultrasound fusion. They commonly use generic handheld ultrasound probes retrofitted for fusion biopsy. Robotic probe manipulation has the potential to reduce the required training, skills, and outcome variability among urologists. Rather than retrofitting an ultrasound probe, we developed a novel cohesive ultrasound-robotic probe (ProBot) that enables a novel needle insertion path.

methodsTissue-probe contact frequently deforms the prostate contributing to fusion errors. To minimize deformations, ProBot uses a side-fire probe and its only motion is a robotic rotation about its axis, which can't force the gland. An additional robotic angulation of the needle allows targeting any gland location. As such, only 2 degrees-of-freedom are required for prostate biopsy. However, the probe and robot must allow clearance to angle the needle, thus a special probe and Remote-Center-of-Motion (RCM) robot kinematics were developed. We present their design, ProBot prototype, and adapters for transrectal and transperineal needle access.

resultsPre-clinical tests showed sub-millimeter targeting errors and validated the sterilization process. With IRB approval, transrectal prostate biopsy was successfully performed in two patients.

conclusionProBot is a novel device for prostate biopsy (robotic, simple, compact, precise) with a successful pilot clinical evaluation. SIGNIFICANCE: A precision, skill independent biopsy device can impact the management of PCa. Additional trials are required.

Indexed as

Image-Guided BiopsyProstateProstatic NeoplasmsRobotic Surgical ProceduresUltrasonography, InterventionalEquipment DesignHumansMalePerineumUltrasonography

Identifiers

PMID40779386
PMCPMC12947452

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.