Evidence map›Paper›PMID 40779323›Full record

ArticleStatistics in medicine2025

Doubly Robust Estimation of Marginal Cumulative Incidence Curves for Competing Risk Analysis.

Patrick van Hage, Saskia le Cessie, Marissa C van Maaren, Hein Putter, Nan van Geloven

Abstract read
In one paragraph

Article in Statistics in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Patrick van HageDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.ORCID https://orcid.org/0000-0003-0814-1505
Saskia le CessieDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
Marissa C van MaarenDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands.
Hein PutterDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.ORCID https://orcid.org/0000-0001-5395-1422
Nan van GelovenDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.ORCID https://orcid.org/0000-0002-5600-9093

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Covariate imbalance between treatment groups makes it difficult to compare cumulative incidence curves in competing risk analyses. In this paper, we discuss different methods to estimate adjusted cumulative incidence curves, including inverse probability of treatment weighting and outcome regression modeling. For these methods to work, correct specification of the propensity score model or outcome regression model, respectively, is needed. We introduce a new doubly robust estimator, which requires correct specification of only one of the two models. We conduct a simulation study to assess the performance of these three methods, including scenarios with model misspecification of the relationship between covariates and treatment and/or outcome. We illustrate their usage in a cohort study of breast cancer patients estimating covariate-adjusted marginal cumulative incidence curves for recurrence, second primary tumor development, and death after undergoing mastectomy treatment or breast-conserving therapy. Our study points out the advantages and disadvantages of each covariate adjustment method when applied in competing risk analysis.

Indexed as

Models, StatisticalBreast NeoplasmsCohort StudiesComputer SimulationFemaleHumansIncidenceMastectomyNeoplasm Recurrence, LocalNeoplasms, Second PrimaryPropensity ScoreRegression AnalysisRisk Assessmentcancercausal inferencecompeting riskcumulative incidencedoubly robust

Identifiers

PMID40779323
PMCPMC12333911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.