Evidence map›Paper›PMID 40779286›Full record

ArticleMolecular imaging and biology2025

CREBBP Mutation as a Culprit for Negative SSTR2 PET in Neuroendocrine Tumors.

Arvin Haj-Mirzaian, Shadi A Esfahani, Umar Mahmood, Pedram Heidari

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Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Arvin Haj-MirzaianDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Shadi A EsfahaniDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Umar MahmoodDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Pedram HeidariDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. heidari.pedram@mgh.harvard.edu.ORCID 0000-0001-6383-465X

Funding

Granzyme B PET imaging as a marker of inflammatory bowel disease activityR01DK123143 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MAHMOOD, UMAR · 2020 to 2023
$2.3M
Enhancing the therapeutic effect of receptor radionuclide therapy in neuroendocrine tumors by somatostatin receptor upregulationK08CA249047 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI HEIDARI, PEDRAM · 2020 to 2024
$1.3M
Molecular Imaging of Fibrosis for Improved Treatment Planning of Pancreatic Ductal AdenocarcinomaK08CA259626 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Shadi Abdar Esfahani · 2022 to 2026
$1.3M
NCI NIH HHS K08 CA249047NCI NIH HHS K08 CA259626NIH HHS K08CA249047NIH HHS K08CA259626NIH HHS R01DK123143
6 · The paper itself

Abstract

purposeThis study aimed to elucidate the molecular and genetic factors contributing to negative

methodsA total of 18 patients with lung, ileal, or pancreatic NETs who underwent

resultsOur analysis identified an association between negative

conclusionThis study suggests that CREBBP mutations in NETs may potentially alter SSTR2 expression, indicating that patients with the mutated CREBBP genotype may not be suitable candidates for SSTR2-targeted PET imaging and radionuclide therapy.

Indexed as

CREB-Binding ProteinMutationNeuroendocrine TumorsPositron-Emission TomographyPositron Emission Tomography Computed TomographyReceptors, SomatostatinAdultAgedExome SequencingFemaleHumansMaleMiddle AgedOrganometallic CompoundsRetrospective StudiesCREB-Binding ProteinCREBBP protein, humangallium Ga 68 dotatateOrganometallic CompoundsReceptors, SomatostatinSSTR2 protein, human⁶⁸Ga-DOTATATEMutationNeuroendocrine tumorsPET imagingSomatostatin receptor 2

Identifiers

PMID40779286
PMCPMC13060772

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.