Evidence map›Paper›PMID 40779284›Full record

ArticleJournal of assisted reproduction and genetics2025

Spermatozoal sialidases NEU1 and NEU3 are potential predictors for fertilization rate in IVF: a prospective cohort study.

Xin Yuan, Jiajie Li, Tang Deng, Li Yang, Yilun Wu, Liangchen Xiang, Fang Yuan, Xinrui Sun, Yi Xia, Yihong Yang and 3 more

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In one paragraph

Article in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Xin Yuan *Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Jiajie Li *Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Tang Deng *Center for Reproductive Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Li YangCenter for Reproductive Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Yilun WuCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Liangchen XiangNational Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Fang YuanCenter for Reproductive Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Xinrui SunCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Yi XiaCenter for Reproductive Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Yihong YangCenter for Reproductive Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Yi ZhangCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China. 349777010@qq.com.
Fang MaCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China. mafangmed@126.com.
Yan WangCenter for Reproductive Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China. wangyy1210@163.com.ORCID http://orcid.org/0000-0003-2426-2542

Funding

National Natural Science Foundation of China 31470797Science-technology Support Plan Projects in Sichuan Province of China 2023NSFSC0629
6 · The paper itself

Abstract

purposeThis study aimed to explore the roles of spermatozoal sialidase NEU1 and NEU3 in affecting the fertilization rate of in vitro fertilization (IVF), and whether sperm sialidase NEU1 and NEU3 can be used as predictors of IVF outcome. MATERIAL AND

methodsThis was a prospective cohort study that collected semen samples from 194 IVF couples between January 2024 and April 2024. Patients were grouped based on oocyte maturity and routine semen analysis. Detection of sperm NEU1 and NEU3 was carried out in semen from the same ejaculate for IVF by using flow cytometry, followed by correlation analysis with fertilization rates.

resultsNEU1 and NEU3 are independent indicators separate from regular semen parameters. With a metaphase II (MII) rate ≥80% and normal semen routine analysis, sperm NEU1 (P = 0.0300) and NEU3 (P = 0.0253) levels were significantly different demarcated by 80% fertilization rate. Lower NEU1 and NEU3 expression on sperm is associated with lower fertilization rates. ROC curve analyses displaying the diagnostic accuracy of NEU1 (P = 0.0306, AUC = 0.660) and NEU3 (P = 0.0259, AUC = 0.665). χ

conclusionsNEU1 and NEU3 on sperm can predict the IVF fertilization outcome in the group with oocyte MII rate ≥80%. The protein levels of NEU1 and NEU3 on sperm could be a new index for assisted reproductive technology (ART).

Indexed as

Fertilization in VitroNeuraminidaseSpermatozoaAdultFemaleFertilizationHumansMaleOocytesPregnancyPregnancy RateProspective StudiesSemen AnalysisNEU1 protein, humanNeu3 protein, humanNeuraminidaseFertilization rateIn vitro fertilization (IVF)Male fertilitySialidaseSpermatozoa

Identifiers

PMID40779284
PMCPMC12559566

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