Evidence map›Paper›PMID 40779251›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Phosphatidic acid production on the vacuole harboring

Hiromu Oide, Tomoko Kubori, Hiroki Nagai, Takashi Nozawa, Ichiro Nakagawa, Miwa Sasai, Masahiro Yamamoto, Kohei Arasaki

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hiromu OideDepartment of Biomedical Sciences, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.
Tomoko KuboriDepartment of Microbiology, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan.ORCID 0000-0003-1098-6021
Hiroki NagaiDepartment of Microbiology, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan.ORCID 0000-0003-1659-2197
Takashi NozawaDepartment of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Ichiro NakagawaDepartment of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Miwa SasaiDepartment of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.ORCID 0000-0001-6440-3958
Masahiro YamamotoDepartment of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.ORCID 0000-0002-6821-2785
Kohei ArasakiDepartment of Biomedical Sciences, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.ORCID 0000-0003-0647-3565

Funding

Japan Agency for Medical Research and Development (AMED) JP23fk0108682MEXT | Japan Science and Technology Agency (JST) JPMJMS2025MEXT | Japan Society for the Promotion of Science (JSPS) 18H02656MEXT | Japan Society for the Promotion of Science (JSPS) 20B304MEXT | Japan Society for the Promotion of Science (JSPS) 20H05772MEXT | Japan Society for the Promotion of Science (JSPS) 22H02867MEXT | Japan Society for the Promotion of Science (JSPS) 23H02716MEXT | Japan Society for the Promotion of Science (JSPS) 23K24129MEXT | Japan Society for the Promotion of Science (JSPS) 23K27407MEXT | Japan Society for the Promotion of Science (JSPS) 25K02494MEXT | JST | Fusion Oriented REsearch for disruptive Science and Technology (FOREST) JPMJFR206DNaito Foundation () N/ATakeda Science Foundation (TSF) N/A
6 · The paper itself

Abstract

The interferon (IFN)-inducible GTPases play a crucial role in cell autonomous immunity against intracellular pathogens. Particularly, these GTPases directly recognize the host membrane-derived vacuole containing pathogens and subsequently destroy it. Although it has been revealed that these GTPases target the membrane of

Indexed as

GTP-Binding ProteinsGTP PhosphohydrolasesInterferonsLegionella pneumophilaPhosphatidic AcidsVacuolesAnimalsBacterial ProteinsHumansLegionnaires' DiseaseMiceBacterial ProteinsGbp2 protein, mouseGTP-Binding ProteinsGTP PhosphohydrolasesInterferonsPhosphatidic Acidscell autonomous immunityGBPLegionella pneumophilaLpg2552phosphatidic acid

Identifiers

PMID40779251
PMCPMC12358870

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.