ArticleJournal of endocrinological investigation2025
Sweeteners and puberty: investigating genetic and dietary influences on central precocious puberty.
Article in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Chronic Aspartame Exposure Leading to Hypertension in Mice may be Related to the Activation of the Wnt/β-Catenin Signaling Pathway in the Hypothalamus.Molecular nutrition & food research · 2026Article
- Effect of High Intensity Sweeteners on the Reproductive System: From the Onset of Puberty to Menstrual Health: A Comprehensive Review of Human and Animal Evidence.International journal of women's health · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Central precocious puberty (CPP) is characterized by the early onset of secondary sexual characteristics caused by premature activation of the hypothalamic-pituitary-gonadal axis. CPP can result in short stature, reproductive health complications, and psychosocial challenges. The rising prevalence of CPP underscores the urgency of investigating the genetic and dietary factors that influence its development to reduce long-term health and developmental effects. CPP was diagnosed in 481 participants. Aspartame, sucralose, glycyrrhizin, and added sugars were significantly linked to increased CPP risk, particularly in genetically predisposed individuals. A dose-dependent relationship was also identified, with higher sweetener intake associated with a greater risk of CPP. Gender-specific effects were also discovered, with sucralose being strongly associated with CPP in boys and glycyrrhizin, sucralose, and added sugar all being strongly associated with CPP in girls. The effects of the interaction between genetic predisposition and sweetener intake on this risk were non-significant. Sweetener consumption and high genetic predisposition independently increase the risk of CPP. Therefore, combining genetic and dietary assessments can guide prevention strategies for at-risk children, reducing the long-term health effects of early puberty.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.