Induction of ER stress-mediated apoptosis in breast cancer cell line by the powerful alkylating agent bendamustine and insights into its molecular mechanisms.

Ganesh Sankaralingam, Kanimozhi Subramaniyan, K Ezhilarasi, Dhamodharan Umapathy, Remya Rajan Renuka, MukeshKumar Dharmalingam Jothinathan, Shenbhagaraman Ramalingam

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Article in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Ganesh SankaralingamCenter for Materials Engineering and Regenerative Medicine, Bharath Institute of Research and Higher Education, Chennai, 600073, Tamil Nadu, India.

Kanimozhi SubramaniyanDepartment of Biotechnology, Bharath Institute of Research and Higher Education, Chennai, 600073, Tamil Nadu, India.

K EzhilarasiScudder Memorial Hospital, Ranipet, 632401, Tamil Nadu, India.

Dhamodharan UmapathyDKM Centre for Research and Innovation, DKM College for Women, Sainathapuram, RV Nagar, Vellore, Tamil Nadu, India.

Remya Rajan RenukaCentre for Stem Cell Mediated Advanced Research Therapeutics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, 600077, Tamil Nadu, India.

MukeshKumar Dharmalingam JothinathanDepartment of Biochemistry, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 602105, Tamil Nadu, India.

Shenbhagaraman RamalingamDepartment of ENT, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 602105, Tamil Nadu, India. shenbhagaraman@gmail.com.

Funding

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6 · The paper itself

Abstract

Bendamustine, an alkylating agent used in treating hematological cancers like non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL), has recently garnered attention for its potential in breast cancer therapy. This study explores its anticancer effects and molecular mechanisms in breast cancer cells. MDA-MB-231 cells were exposed to various concentrations of bendamustine (0-50 µM), and cytotoxicity was assessed using Alamar Blue and LDH assays, revealing a dose-dependent reduction in cell viability with an IC

Indexed as

Antineoplastic Agents, AlkylatingApoptosisBendamustine HydrochlorideBreast NeoplasmsEndoplasmic Reticulum StressCell Line, TumorCell SurvivalFemaleHumansReactive Oxygen SpeciesAntineoplastic Agents, AlkylatingBendamustine HydrochlorideReactive Oxygen SpeciesApoptosisBendamustineBreast cancerEndoplasmic reticulum stressReactive oxygen species

Identifiers

PMID40779231

DOI10.3390/cancers13071702

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.