ArticleMolecular biology reports2025
Elucidating chromosomal ARGs in environmental Aeromonas spp. from hospital effluent impacted waterbodies: antagonistic potential by plant-based antimicrobials.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Intergeneric conjugative transfer of plasmid-associated antibiotic resistance genes from environmental Aeromonas spp. to gram-negative recipient strains.Molecular biology reports · 2026Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study assesses the prevalence of Antibiotic Resistance Genes (ARGs) in multidrug-resistant (MDR) bacteria from hospital effluent-contaminated water bodies and to explore phytoconstituents from Ocimum species as alternative control agents against resistant strains. MATERIALS AND
resultsWater samples were collected from four different sites across two water bodies receiving hospital wastewater. Bacterial isolates exhibiting MDR were obtained and taxonomically identified as Aeromonas spp. via 16S rRNA gene sequencing. Chromosomally encoded ARGs were predicted using the ResFinder database. To investigate alternative antimicrobial strategies, leaf extracts of Ocimum tenuiflorum and Ocimum gratissimum were prepared. The potential mechanism of action of the extracts were examined using field emission scanning electron microscopy (FESEM), which revealed morphological damage to bacterial cell structures. Molecular docking evaluated the binding affinities of bioactive constituents from Ocimum extracts against resistance-associated proteins, identifying potential inhibitors that may suppress resistance mechanisms. The in-silico study was validated through amplification of ARGs from bacterial genomic DNA followed by cloning of the ARGs and sequencing revealed conserved motifs associated with resistance phenotypes.
conclusionThis study highlights the occurrence of MDR Aeromonas spp. with insights into the environmental dissemination of resistance genes and identifies potential plant-derivatives capable of targeting resistance mechanisms.
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