Evidence map›Paper›PMID 40779161›Full record

ArticleSkeletal radiology2025

Optimizing contrast timing in photon-counting detector CT for the assessment of peripheral arthritis.

Akos Horvath, Rita Csercsik, Janos Norbert Gyebnar, Daniel Sandor Veres, Pal Maurovich-Horvat, Akos Menyhart, Viktoria Gyergyoi, Peter Vince Balint, Nikolett Marton

Abstract read
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In one paragraph

Article in Skeletal radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Akos HorvathDepartment of Radiology, Clinic for Medical Imaging, Semmelweis University, 2. Koranyi Sandor Utca, Budapest, 1083, Hungary.ORCID http://orcid.org/0009-0001-2855-9709
Rita CsercsikDepartment of Radiology, Clinic for Medical Imaging, Semmelweis University, 2. Koranyi Sandor Utca, Budapest, 1083, Hungary.
Janos Norbert GyebnarDepartment of Radiology, Clinic for Medical Imaging, Semmelweis University, 2. Koranyi Sandor Utca, Budapest, 1083, Hungary.
Daniel Sandor VeresDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Pal Maurovich-HorvatDepartment of Radiology, Clinic for Medical Imaging, Semmelweis University, 2. Koranyi Sandor Utca, Budapest, 1083, Hungary.
Akos MenyhartDepartment of Rheumatology, Clinic for Rheumatology and Immunology, Semmelweis University, Budapest, Hungary.
Viktoria GyergyoiDepartment of Rheumatology, Clinic for Rheumatology and Immunology, Semmelweis University, Budapest, Hungary.
Peter Vince BalintDepartment of Radiology, Clinic for Medical Imaging, Semmelweis University, 2. Koranyi Sandor Utca, Budapest, 1083, Hungary.
Nikolett MartonDepartment of Radiology, Clinic for Medical Imaging, Semmelweis University, 2. Koranyi Sandor Utca, Budapest, 1083, Hungary. marton.nikol@gmail.com.ORCID http://orcid.org/0000-0002-7351-6361

Funding

Bolyai Research Scholarship, Hungary BO/00270/22/5European Society for Musculoskeletal Radiology (ESSR) Arthritis Subcommittee 2024 - travel grant (poster)New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research Development and Innovation Fund, Hungary ÚNKP-23-5
6 · The paper itself

Abstract

objectivePhoton-counting detector CT (PCD-CT) allows for iodine mapping of inflamed tissues in peripheral immune-mediated arthritis, supporting diagnosis and disease activity assessment. This study aims to identify the optimal timing for image acquisition after intravenous iodinated contrast administration to maximize enhancement and contrast with surrounding tissues.

methodsHigh-resolution PCD-CT scans of bilateral wrist-hand regions were obtained from 26 patients with peripheral arthritis, both native and post-contrast (1 ml/kg intravenous iodinated contrast at 2.5 ml/sec flow) at 120-, 180-, and 240-s delay phases. Iodine maps were constructed from spectral data. Phases were compared based on densities and iodine concentrations measured in synovial, tenosynovial, and periungual tissues, with muscle, fat, and vessels as controls. We used descriptive statistics and mixed-effects linear regression inferential models for the comparisons. Synovitis and tenosynovitis were verified by ultrasound measurements.

resultsNo significant differences (p > 0.05) were found in iodine concentration or density across the 120-, 180-, and 240-s post-contrast phases in inflamed synovial, tenosynovial, and periungual soft tissues. Inflamed tissues showed significant and consistent differences in iodine concentration from muscle and fat (p < 0.0001) across all phases, while the greatest differentiation from vessels was in the 120-s phase. The effective dose was identical across all post-contrast phases (0.028 ± 0.0035 mSv).

conclusionIodine uptake in inflamed tissues was identical across all three post-contrast phases. However, the 120-s phase offered the highest contrast between inflammation and surrounding vascular structures while minimizing scan time, supporting its use for standardized follow-up imaging.

Indexed as

ArthritisContrast MediaRadiographic Image EnhancementTomography, X-Ray ComputedAdultAgedFemaleHumansMaleMiddle AgedPhotonsContrast MediaHandIodine mappingPeripheral arthritisPhoton-counting detector CTPsoriatic arthritisRheumatoid arthritisSpectral CTSynovitisTenosynovitisWrist

Identifiers

PMID40779161
PMCPMC12460460

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.