ArticleDiscover oncology2025
Advances and emerging trends in the tumor microenvironment of colorectal cancer liver metastasis: a bibliometric analysis.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Mechanisms and advantages of natural derived small molecule compounds in the prevention and treatment of colorectal cancer: a review.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundColorectal cancer liver metastasis (CRLM) significantly reduces the survival rate of colorectal cancer patients and increases the complexity of treatment decisions. Analyzing the dynamic interplay of cellular subtypes and phenotypic characteristics in the tumor microenvironment (TME) is essential for developing effective anti-cancer therapies and improving prognosis. Consequently, this research employs bibliometric methods to systematically examine current research focus and emerging developments in the TME associated with CRLM.
methodsA systematic search of the Web of Science Core Collection was undertaken to retrieve studies released between January 2012 and March 2025. CiteSpace and VOSviewer were mainly used to analyze and visualize country, institution, author, journal, reference, and keyword.
resultsA total of 362 studies were ultimately included in the analysis. China emerged as the leading contributor, followed by the USA, with notable collaborative strength between these nations. Among the institutions, Sun Yat-sen University has the highest publication output. Huang Leaf was the most productive author and Cancer emerged as the most prolific journal. Timeline analysis of keyword clusters demonstrated a persistent research focus on CRLM, liver metastasis, and tumor microenvironment, with immune-related keywords ("immunotherapy," "immune microenvironment," and "PD-L1") gradually emerging since 2020.
conclusionsScholars are progressively unraveling the full complexity of the TME in CRLM, and strengthening international cooperation will help accelerate this process. Understanding the dynamic evolution mechanisms of TME following drug treatment and identifying novel therapeutic targets are priorities for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.