Evidence map›Paper›PMID 40779131›Full record

ArticleActa neurochirurgica2025

Recurrence patterns and clinical outcomes in adult cerebellar glioblastoma.

Sogo Oki, Shigeru Yamaguchi, Yukitomo Ishi, Hiroaki Motegi, Masayuki Gekka, Zen-Ichi Tanei, Hiromi Kanno-Okada, Emi Takakuwa, Satoshi Tanaka, Takashi Mori and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neurochirurgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. All-trans retinoic acid suppresses CD8Signal transduction and targeted therapy · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Sogo OkiDepartment of Neurosurgery, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-Ku, Sapporo, Hokkaido, Japan.
Shigeru YamaguchiDepartment of Neurosurgery, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-Ku, Sapporo, Hokkaido, Japan. yama-shu@med.hokudai.ac.jp.
Yukitomo IshiDepartment of Neurosurgery, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-Ku, Sapporo, Hokkaido, Japan.
Hiroaki MotegiDepartment of Neurosurgery, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-Ku, Sapporo, Hokkaido, Japan.
Masayuki GekkaDepartment of Neurosurgery, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-Ku, Sapporo, Hokkaido, Japan.
Zen-Ichi TaneiDepartment of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Hiromi Kanno-OkadaDepartment of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.
Emi TakakuwaDepartment of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.
Satoshi TanakaCenter for Cause of Death Investigation, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Takashi MoriDepartment of Radiation Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Kentaro NishiokaGlobal Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Hidefumi AoyamaDepartment of Radiation Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Shinya TanakaDepartment of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Miki FujimuraDepartment of Neurosurgery, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-Ku, Sapporo, Hokkaido, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebellar glioblastoma in adults is a rare brain tumor with poor outcomes. This study aimed to assess the clinical characteristics, genetic features, and prognosis of a series of cerebellar glioblastomas, with special attention to their recurrence patterns.

methodsWe retrospectively analyzed patients who underwent treatment between 2008 and 2023. The patient characteristics, treatment methods, genetic features, and prognoses were assessed.

resultsAmong 274 cases of histological glioblastomas, eleven patients with cerebellar glioblastomas were identified. Pathological results revealed microvascular proliferation and/or necrosis in all cases. All patients underwent surgery and local radiotherapy combined with temozolomide chemotherapy. The median progression-free survival and overall survival were 15.3 months and 22.8 months, respectively. Subventricular zone involvement was recognized in ten patients. Of the eight patients who experienced recurrence, seven had distant or disseminated recurrence, and only one experienced local recurrence. None of the tumors harbored mutations in the IDH1/2, H3F3A, or TERT promoters. Three patients showed negative expression of O

conclusionsIn our cohort, cerebellar glioblastomas showed clinical characteristics such as recurrence patterns and genetic features such as IDH, H3F3A, and TERT promoter regions that differed from those of typical supratentorial gliomas. Further studies are necessary to fully elucidate the clinical characteristics.

Indexed as

Cerebellar NeoplasmsGlioblastomaNeoplasm Recurrence, LocalAdultAgedAntineoplastic Agents, AlkylatingDNA Modification MethylasesDNA Repair EnzymesFemaleHumansIsocitrate DehydrogenaseMaleMiddle AgedPrognosisRetrospective StudiesTelomeraseAntineoplastic Agents, AlkylatingDNA Modification MethylasesDNA Repair EnzymesIsocitrate DehydrogenaseMGMT protein, humanTelomeraseTemozolomideTumor Suppressor ProteinsCerebellumGBMGlioblastomaHistologicalRecurrence

Identifiers

PMID40779131
PMCPMC12334374

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.