Evidence map›Paper›PMID 40779128›Full record

ArticleCell biochemistry and biophysics2025

Energy Decomposition-Driven Design of Trop2-Targeting Peptide.

Yu-Chao Meng, He Liu, Bi-Shao Sun, Hong-Yuan Liu, Hong-Wei Li, Qiu-Yu Liao, Mouxin Huang, Qin Ouyang

Abstract read
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In one paragraph

Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Peptide Aptamers: Innovative Design and Applications in Pathogen Detection.Chembiochem : a European journal of chemical biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu-Chao MengDepartment of Medicinal Chemistry, Third Military Medical University, Chongqing, China.
He LiuDepartment of Medicinal Chemistry, Third Military Medical University, Chongqing, China.
Bi-Shao SunDepartment of Medicinal Chemistry, Third Military Medical University, Chongqing, China.
Hong-Yuan LiuDepartment of Medicinal Chemistry, Third Military Medical University, Chongqing, China.
Hong-Wei LiDepartment of Medicinal Chemistry, Third Military Medical University, Chongqing, China.
Qiu-Yu LiaoDepartment of Medicinal Chemistry, Third Military Medical University, Chongqing, China.
Mouxin HuangDepartment of Medicinal Chemistry, Third Military Medical University, Chongqing, China. mxhuang@tmmu.edu.cn.
Qin OuyangDepartment of Medicinal Chemistry, Third Military Medical University, Chongqing, China. ouyangq@tmmu.edu.cn.

Funding

China Postdoctoral Science Foundation BX20230486Chongqing Youth Innovation Talent Program CSTB2024NSCQ-QCXMX0047National Key R&D program of China 2022YFC2502501Natural Science Foundation of China 22307141, 82273775Young Talents Training Program of Third Military Medical University 2022XQN06
6 · The paper itself

Abstract

Trophoblast cell surface antigen-2 (Trop2) is a transmembrane glycoprotein that has been identified as a biomarker of triple negative breast cancer (TNBC). Current therapeutic strategies targeting Trop2 focus on antibody-drug conjugates (ADCs), while other types of conjugates have seen limited development due to the lack of high-affinity ligands. Herein, we constructed the Trop2-nanobody interaction model by deep learning server and molecular dynamics simulation. Several peptide ligands were designed based on fragments of nanobody binding site, one of which demonstrated binding affinity to Trop2. We believe that this study provides a promising candidate ligand for the development of Trop2-targeted peptide-drug conjugates (PDCs) and will contribute to expanding the diversity of Trop2-targeted cancer therapy.

Indexed as

Antigens, NeoplasmCell Adhesion MoleculesDrug DesignPeptidesAmino Acid SequenceBinding SitesHumansLigandsMolecular Dynamics SimulationProtein BindingThermodynamicsAntigens, NeoplasmCell Adhesion MoleculesLigandsPeptidesTACSTD2 protein, humanMolecular dynamicsNanobodyPeptide ligandTrop2

Identifiers

PMID40779128

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.