ArticleCell biochemistry and biophysics2025
Cytotoxicity and Antiplatelet Activity of Cationic Antimicrobial Peptides of the Medicinal Leech Hirudo Medicinalis.
Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Peptidomics Landscape of Intrahepatic Cholestasis of Pregnancy and its Molecular Mechanism Investigation.Cell biochemistry and biophysics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cationic antimicrobial peptides (CAMPs) are known as promising candidates for the development of antimicrobial drugs that do not induce resistance in pathogenic bacteria. The use of such drugs in systemic administration is the most promising hence the need to investigate the effects of CAMPs on human blood cells. Platelets are fragments of blood cells capable of forming clots to cover sites of vascular injury. In this work, the toxicity of 9 CAMPs from the medicinal leech Hirudo medicinalis to platelets was compared in the presence of blood plasma and in plasma-free media. The former conditions resulted in reduced toxicity, likely due to the binding of CAMPs to plasma components, in particular to human albumin. It was shown that all peptides affected ADP-induced platelet aggregation even at subtoxic concentrations. These results should be taken into account when developing a new generation of antibacterial agents based on the CAMPs of Hirudo medicinalis.
Indexed as
Identifiers
40779125What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.