Evidence map›Paper›PMID 40779102›Full record

ReviewMethods in molecular biology (Clifton, N.J.)2025

Bioconductor's Computational Ecosystem for Genomic Data Science in Cancer.

Marcel Ramos, Lori Shepherd, Nathan C Sheffield, Alexandru Mahmoud, Hervé Pagès, Andres Wokaty, Dario Righelli, Davide Risso, Sean Davis, Sehyun Oh and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marcel RamosCity University of New York School of Public Health, New York, NY, USA.ORCID https://orcid.org/0000-0002-3242-0582
Lori ShepherdRoswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID https://orcid.org/0000-0002-5910-4010
Nathan C SheffieldUniversity of Virginia, Charlottesville, VA, USA.ORCID https://orcid.org/0000-0001-5643-4068
Alexandru MahmoudChanning Division of Network Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-3779-492X
Hervé PagèsFred Hutchinson Cancer Center, Seattle, WA, USA.ORCID https://orcid.org/0009-0002-8272-4522
Andres WokatyCity University of New York School of Public Health, New York, NY, USA.ORCID https://orcid.org/0009-0008-0900-8793
Dario RighelliDepartment of Electrical Engineering and Information Technology, University of Naples "Federico II", Naples, Italy.ORCID https://orcid.org/0000-0002-2687-9928
Davide RissoDepartment of Statistical Sciences, University of Padova, Padova, Italy.ORCID https://orcid.org/0000-0001-8508-5012
Sean DavisUniversity of Colorado Anschutz School of Medicine, Aurora, CO, USA.ORCID https://orcid.org/0000-0002-8991-6458
Sehyun OhCity University of New York School of Public Health, New York, NY, USA.ORCID https://orcid.org/0000-0002-9490-3061
Levi WaldronCity University of New York School of Public Health, New York, NY, USA.ORCID https://orcid.org/0000-0003-2725-0694
Martin MorganRoswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID https://orcid.org/0000-0002-5874-8148
Vincent CareyChanning Division of Network Medicine, Mass General Brigham, Harvard Medical School, Buffalo, NY, USA.ORCID https://orcid.org/0000-0003-4046-0063

Funding

Cancer Genomics:Integrative and Scalable Solutions in R / BioconductorU24CA180996 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MORGAN, MARTIN T, WALDRON, LEVI · 2014 to 2023
$6.9M
NCI NIH HHS U24 CA180996
6 · The paper itself

Abstract

The Bioconductor project enters its third decade with over two thousand packages for genomic data science, over 100,000 annotation and experiment resources, and a global system for convenient distribution to researchers. Over 60,000 PubMed Central citations and terabytes of content shipped per month attest to the impact of the project on cancer genomic data science. This report provides an overview of cancer genomics resources in Bioconductor. After an overview of Bioconductor project principles, we address exploration of institutionally curated cancer genomics data such as TCGA. We then review genomic annotation and ontology resources relevant to cancer and then briefly survey analytical workflows addressing specific topics in cancer genomics. Concluding sections cover how new software and data resources are brought into the ecosystem and how the project is tackling needs for training of the research workforce. Bioconductor's strategies for supporting methods developers and researchers in cancer genomics are evolving along with experimental and computational technologies. All the tools described in this report are backed by regularly maintained learning resources that can be used locally or in cloud computing environments.

Indexed as

Computational BiologyData ScienceGenomicsNeoplasmsSoftwareDatabases, GeneticHumansCancer genomicsdata structuresepigenomicsmutationsontologyopen source softwarespatial transcriptomicstranscriptomics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.