Evidence map›Paper›PMID 40779095›Full record

SynthesisThe international journal of cardiovascular imaging2026

Impact of mitral regurgitation severity on thromboembolic risk in atrial fibrillation: a comprehensive systematic review and meta-analysis.

Adil Salihu, Georgios Tzimas, Pierre Monney, Niccolo Maurizi, Ioannis Skalidis, Dimitri Arangalage, Denise Auberson, Sarah Hugelshofer, Cheryl Teres, Olivier Muller and 2 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The international journal of cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Adil SalihuService of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland.
Georgios TzimasService of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland.
Pierre MonneyService of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland.
Niccolo MauriziService of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland.
Ioannis SkalidisService of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland.
Dimitri ArangalageService of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland.
Denise AubersonService of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland.
Sarah HugelshoferService of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland.
Cheryl TeresService of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland.
Olivier MullerService of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland.
Henri LuService of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland.
Panagiotis AntiochosService of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland. Panagiotis.antiochos@chuv.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) is associated with a heightened risk of thromboembolic events (TE). Whether severe mitral regurgitation (MR) has a protective effect against thrombus formation in AF remains unclear. We aimed to evaluate the impact of MR severity on thromboembolic risk in patients with AF. This systematic review with meta-analysis included data from eight studies, from 1998 to 2022. All studies reported the prevalence of TE according to MR severity, in patients with non-valvular AF, defined as the absence of prosthetic/repaired mitral valve or moderate or more severe mitral stenosis. TE was defined as stroke, transient ischemic attack, another arterial embolic event, or presence of thrombus in the left atrium. Eight studies with a total of 21,821 patients (54% male, mean age 70 ± 11 years) were identified. The overall prevalence of TE was 6.0%. No significant difference was observed in the prevalence of TE based on MR severity (no or mild MR: 5.9%, moderate or more severe MR: 6.8%, odds ratio: 1.11, 95% confidence interval: 0.77-1.73, p = 0.64). When specifically examining studies that exclusively reported either embolic or thrombotic events, there was no statistically significant difference in the incidence rates of events observed across the different categories of MR severity. Our analysis found no significant association between MR severity and the risk for TE, in patients with non-valvular AF. This suggests that MR may not be a determining factor for thromboembolic risk in this population.Clinical Trial registration (PROSPERO) CRD42024504403.

Indexed as

Atrial FibrillationMitral ValveMitral Valve InsufficiencyThromboembolismAgedAged, 80 and overFemaleHumansIncidenceMaleMiddle AgedPrevalencePrognosisRisk AssessmentRisk FactorsSeverity of Illness IndexAtrial fibrillationLeft atrial thrombusMitral regurgitationThromboembolic event

Identifiers

PMID40779095
PMCPMC13375830

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.