ReviewCellular and molecular life sciences : CMLS2025
Regulation and dysregulation of microRNA - transcription factor axes in differentiation and neuroblastoma.
Review in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- LncRNA EWSAT1 promotes colorectal cancer progression by regulating the miR-330-5p/CPEB4 axis.American journal of translational research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development is characterized by dynamic changes in gene expression as cells traverse genetic pathways and make lineage-specific commitments. Transcription factors, which drive gene expression, and microRNAs, the largest class of post-transcriptional regulators, often function together within the same genetic networks. These interactions frequently include direct regulation of one another and shared target genes, forming feedback and feedforward loops that fine-tune gene expression to establish and maintain cell identity. The interplay between transcriptional and post-transcriptional regulation is particularly extensive during development, where disruptions in gene expression programs can cause cells to become trapped in immature proliferative states that result in paediatric cancers. This review focuses on the intricate cross-regulation between transcription factors and microRNAs, highlighting their contributions to developmental cancers with a particular emphasis on neuroblastoma, the most prevalent extracranial solid tumour in children, which arises from the failure of neural crest-derived cells to properly differentiate during sympathoadrenal development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.