Evidence map›Paper›PMID 40778948›Full record

ArticleCellular and molecular life sciences : CMLS2025

Spider venom peptides with unique fold selectively block Shaker-type potassium channels.

Alexey I Kuzmenkov, Valentina A Iunusova, Vladislav A Lushpa, Yakov A Deyev, Vladislav V Babenko, Daniil V Osipov, Antonina A Berkut, Jan Tytgat, Eduard V Bocharov, David J Adams and 2 more

Abstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexey I KuzmenkovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia. aleksey.kuzmenkov@gmail.com.ORCID http://orcid.org/0000-0002-5416-1825
Valentina A IunusovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
Vladislav A LushpaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
Yakov A DeyevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
Vladislav V BabenkoLopukhin Federal Research and Clinical Centre of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia.
Daniil V OsipovEntomology Department, Moscow Zoo, Moscow, 123557, Russia.
Antonina A BerkutShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
Jan TytgatToxicology and Pharmacology, KU Leuven, Leuven, B-3000, Belgium.
Eduard V BocharovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
David J AdamsFaculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia. djadams@uow.edu.au.ORCID http://orcid.org/0000-0002-7030-2288
Rocio K Finol-UrdanetaFaculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia.ORCID http://orcid.org/0000-0003-2157-4532
Alexander A VassilevskiShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia. avas@ibch.ru.ORCID http://orcid.org/0000-0002-1359-0076

Funding

Australian Research Council DP210102405Australian Research Council LE180100066Rusian Science Foundation 22-74-10028
6 · The paper itself

Abstract

Natural toxins are highly effective at targeting ion channels with high selectivity and potency. To date, all identified spider venom peptide toxins that modulate voltage-gated potassium (K

Indexed as

PeptidesPotassium Channel BlockersSpider VenomsAmino Acid SequenceAnimalsHumansSpidersPeptidesPotassium Channel BlockersSpider VenomsBlockerDisulfideInhibitor cystine knotIon channelNeurotoxinSpatial structure

Identifiers

PMID40778948
PMCPMC12334782

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.