ArticleOperative neurosurgery (Hagerstown, Md.)2026
Endoscopic Endonasal Approach for Craniopharyngiomas With Intraventricular Extension: Anatomic-Clinical Considerations and Surgical Outcomes in a Series of 61 Patients.
Article in Operative neurosurgery (Hagerstown, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evolution of surgical management and functional outcomes of craniopharyngiomas: a systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- The Evolving Role of the Endoscopic Endonasal Transplanum-Transtuberculum Approach in the Management of Craniopharyngiomas: A Systematic Review of Outcomes, Reconstruction, and Surgical Evolution.Journal of clinical medicine · 2026Review
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8 authors.
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Abstract
BACKGROUND AND
objectivesCraniopharyngiomas (CPs) with intraventricular extension has required often a difficult surgical management. These injuries involve a high degree of endocrinological, visual, and neuropsychological morbidities, which have a huge impact on the patient's quality of life. The advancements of visualization instruments along with development of minimally invasive techniques as the endoscopic endonasal have granted reduction of morbidity and mortality rates. The aim of this retrospective study was to report our experience with the endoscopic endonasal approach in the management of a series of patients affected by CPs with intraventricular extension.
methodsThe authors reviewed data of 61 cases from a series of 164 patients, who underwent an endoscopic endonasal transtuberculum/transplanum approach for the removal of a CP involving the third ventricle between January 2001 and March 2023. Four main third ventricular growth patterns were identified: stalk-infundibulum, infundibulum-ventricular chamber, stalk-infundibulum-ventricular chamber, and ventricular chamber.
resultsSixty-one patients (34 men, 27 women), with mean age of 51.87 years (range 10-79 years ± 13.66 SD), underwent extended endoscopic endonasal approach. Gross total resection was obtained in 65.6% of cases and resulted significantly influenced by the sex (95% CI, 0.080-0.60; P = .02), previous treatment (95% CI, 0.08-0.31; P = .04), and tumor location (95% CI, 0.44-0.10; P = .05). Postoperatively, visual improvement was observed in 40 patients (76.9%). The hypothalamic functions were improved in 6 cases (20%), remained stable in 9 (45%), instead a new-onset of hypothalamic functions disturbances were registered in 5 cases on 31 patients (16.1%). Six postoperative cerebrospinal fluid leaks (9.8%) occurred.
conclusionThe different topographies of intraventricular CPs affect the outcomes of resection. However, the extension of CP in the third ventricle does not represent a limit of the endonasal route; the good outcomes and limited complications confirm that.
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