ArticlePediatric pulmonology2025
Lung Function in a Multiethnic U.S. Cohort of Adolescents and Adults Born Preterm in the New BPD Era.
Article in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Young adults born moderately to extremely preterm have higher eGFR and cystatin C compared to young adults born at term.Pediatric nephrology (Berlin, Germany) · 2026Article
- Neonatal critical illness is associated with pancytopenia development in childhood.medRxiv : the preprint server for health sciences · 2026Article
- Long-term outcomes in adults born preterm with symptomatic patent ductus arteriosus.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Bronchopulmonary dysplasia associated pulmonary hypertension: implications across the lifespan.Paediatric respiratory reviews · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
rationaleExtreme preterm birth is a recognized risk factor for reduced pulmonary function over the lifespan. However, data are lacking in U.S.-born adults and in multiethnic populations.
objectiveTo comprehensively evaluate lung function in adolescents and young adults born premature, and to assess for potential impact of neonatal, racial/ethnic, and socioeconomic risk factors on long-term lung function.
methodsPreterm participants aged 12-40 years of age were recruited from the Parkland Hospital Neonatal ICU Registry (Dallas County, Texas). Preterm and term-born participants completed pulmonary function testing including spirometry, lung volumes, diffusion capacity, and respiratory muscle forces, using Global Lung Initiative race-neutral reference equations. Influence of racial/ethnic background, neonatal factors, and socioeconomic ratings were assessed for preterm participants.
resultsPreterm participants (n = 105; gestational age 29.5 ± 2.5 weeks; current age 26 ± 6 yrs) were significantly more likely than term participants (n = 48; gestational age 39.2 ± 1.1 weeks; current age 29 ± 7 yrs) to have an obstructive or restrictive ventilatory defect (34.4% vs 14.6%, OR 3.06, 95% CI 1.26-7.93), reduced diffusion capacity (16.4% vs 2.1%, OR 9.18, 95% CI 1.47-98.3), and impaired respiratory muscle strength (27.7% vs 4.4%, OR 8.22, 95% CI 2.10-36.2). Neonatal risk factors included history of bronchopulmonary dysplasia and lower weight for gestational age percentile. Lung function was worse in preterm-born Non-Hispanic Black participants compared to preterm-born Hispanic White participants, which could not be explained by available neonatal or socioeconomic factors.
conclusionWhile most moderately to extremely preterm-born individuals have normal lung function, obstructive and restrictive ventilatory defects, reduced diffusion capacity, and impaired respiratory muscle strength are common.
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