Evidence map›Paper›PMID 40778602›Full record

ArticlePediatric pulmonology2025

Sex and Pubertal Status in Relation to Wheezing, Asthma, and Lung Function Development in a Multi-Ethnic Population-Based Prospective Cohort.

Marina Attanasi, Annemiek Mian, Tarik Karramass, Liesbeth Duijts

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marina AttanasiThe Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Annemiek MianThe Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Tarik KarramassThe Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0003-1743-7877
Liesbeth DuijtsDepartment of Pediatrics, Division of Respiratory Medicine and Allergology, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0001-6731-9452

Funding

The Generation R Study is made possible by financial support from the Erasmus Medical Centre, Rotterdam, the Erasmus University Rotterdam and the Netherlands Organization for Health Research and Development. This project received funding for projects from the European Union's Horizon 2020 research and innovation programme (ATHLETE, grant agreement No 874583; and ENDOMIX, grant agreement No 101136566). The researchers are independent from the funders. The study sponsors had no role in the study design, data analysis, interpretation of data, or writing of this report.
6 · The paper itself

Abstract

aimWe examined if sex and puberty are associated with respiratory health, and if associations were modified by ethnicity, body mass index or allergic sensitization.

methodsAmong 3418 children of a multi-ethnic population-based cohort study, medical records provided information on sex. Questionnaires provided information on pubertal stages, wheezing from birth until age 13 years and current asthma at age 13 years. Pre/early, mid, and late developmental stages of breast (girls only), genital (boys only), and pubic hair were based on Tanner stages 1-2, 3-4, and 5, respectively. Spirometry was performed at age 13 years.

resultsGirls had a consistently lower risk of wheezing from birth until age 13 years than boys (overall OR (95% CI) 0.86 (0.74, 0.98)). Additionally, allergic girls had a lower risk of current asthma at age 13 years (0.66 (0.46, 0.94)). Only underweight and overweight/obese girls had lower and higher, respectively, FEV

conclusionOur findings suggest a different risk of respiratory morbidity between girls and boys partly modified by BMI or allergic sensitization, not ethnicity, and that puberty has a positive effect on lung function measures in both sexes.

Indexed as

AsthmaLungPubertyRespiratory SoundsAdolescentBody Mass IndexChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleProspective StudiesRisk FactorsSex Factorschildhoodhormonal influencerespiratory health

Identifiers

PMID40778602
PMCPMC12333329

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.