Evidence map›Paper›PMID 40778549›Full record

ArticleAddiction biology2025

AAV-Mediated Expression of Methamphetamine Monoclonal Antibody Attenuates Methamphetamine Behaviour Sensitization in Mice.

Yun-Hsiang Chen, Tsai-Wei Hung, Yu-Syuan Wang, Eun-Kyung Bae, Kuo-Jen Wu, Yun Wang, Seong-Jin Yu

Abstract read
In one paragraph

Article in Addiction biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yun-Hsiang ChenCenter for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Taiwan.
Tsai-Wei HungCenter for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Taiwan.
Yu-Syuan WangCenter for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Taiwan.
Eun-Kyung BaeCenter for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Taiwan.
Kuo-Jen WuCenter for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Taiwan.
Yun WangCenter for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Taiwan.
Seong-Jin YuCenter for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Taiwan.ORCID 0000-0001-7500-5883

Funding

National Health Research Institutes, Taiwan CS-113-GP-02National Science and Technology Council, Taiwan MOST 107-2314-B-030-009
6 · The paper itself

Abstract

Methamphetamine (Meth) is a psychoactive and neurotoxic chemical. Selective antibodies against Meth molecules have been examined for the treatment of Meth abuse through immunization. Antibodies with high affinity for Meth can capture Meth molecules and reduce Meth response. We previously reported that intraperitoneal administration of adeno-associated virus serotype vector serotype 8 carrying Meth-specific monoclonal antibody transgene (AAV8-MethAb, 2.5 × 10

Indexed as

Amphetamine-Related DisordersAntibodies, MonoclonalBehavior, AnimalCentral Nervous System StimulantsDependovirusMethamphetamineAnimalsDopaminergic NeuronsGenetic VectorsMaleMiceNucleus AccumbensRatsAntibodies, MonoclonalCentral Nervous System StimulantsMethamphetamineadeno‐associated virusantibody therapymethamphetaminesensitization

Identifiers

PMID40778549
PMCPMC12332764

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.