ArticlePacing and clinical electrophysiology : PACE2025
Characteristics of Cardiomyopathy in Patients With Chronic Left Bundle Branch Block Undergoing Right Ventricular Pacing.
Article in Pacing and clinical electrophysiology : PACE, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Characteristics of Cardiomyopathy in Patients With Chronic Left Bundle Branch Block Undergoing Right Ventricular Pacing.Pacing and clinical electrophysiology : PACE · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeft bundle branch block (LBBB) and right ventricular pacing (RVP) are associated with abnormal myocardial mechanics and cardiomyopathy. Consequently, chronic LBBB may increase the risk of heart failure and mortality in patients undergoing RVP.
methodsUsing the TriNetX Analytics Network database, we identified patients who underwent pacemaker implantation between January 1, 2014 and January 1, 2024. Exclusion criteria included a history of heart failure, previous cardiac devices, cardiac resynchronization therapy (CRT) during the index hospitalization, or a left ventricular ejection fraction (LVEF) of less than 50%. The primary outcome incident systolic heart failure and all-cause mortality occurring from the index hospitalization through November 2024.
resultsAmong 70,526 patients undergoing RVP implantation, 3916 (5.6%) had chronic LBBB prior to the procedure, with a median age of 75 ± 15 years. Over a median follow-up of 2.5 years, 5356 (7.6%) developed incident systolic heart failure, and 9714 (13.7%) experienced all-cause mortality. After propensity score matching, chronic LBBB was associated with a higher risk of systolic heart failure (HR: 1.39; 95% CI: 1.20-1.62) but not all-cause mortality (HR: 0.93; 95% CI: 0.83-1.06). Patients with chronic LBBB who developed systolic heart failure were more likely to present with moderately depressed LVEF and require CRT upgrades during follow-up compared to those without chronic LBBB.
conclusionChronic LBBB was associated with a higher risk of systolic heart failure, worse left ventricular function, and greater likelihood of CRT upgrade among patients undergoing RVP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.