Evidence map›Paper›PMID 40778498›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2025

Probabilistic Mapping of Magnetic Resonance-Guided Focused Ultrasound (MRgFUS) Thalamotomy Targets in Essential Tremor and Tremor-Dominant Parkinson's Disease: Insights from a German Cohort.

Jonas Krauss, Neeraj Upadhyay, Veronika Purrer, Valeri Borger, Marcel Daamen, Hannah Weiland, Angelika Maurer, Carsten Schmeel, Alexander Radbruch, Markus Essler and 2 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jonas KraussClinical Functional Imaging Group, Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany.ORCID https://orcid.org/0009-0002-1880-718X
Neeraj UpadhyayClinical Functional Imaging Group, Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany.
Veronika PurrerDepartment of Parkinson, Sleep and Movement Disorders, University Hospital Bonn, Bonn, Germany.
Valeri BorgerDepartment of Neurosurgery, University Hospital Bonn, Bonn, Germany.
Marcel DaamenClinical Functional Imaging Group, Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany.
Hannah WeilandClinical Functional Imaging Group, Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany.
Angelika MaurerClinical Functional Imaging Group, Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany.ORCID https://orcid.org/0000-0002-6067-3253
Carsten SchmeelDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany.
Alexander RadbruchGerman Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany.
Markus EsslerClinical Functional Imaging Group, Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany.
Ullrich WüllnerDepartment of Parkinson, Sleep and Movement Disorders, University Hospital Bonn, Bonn, Germany.ORCID https://orcid.org/0000-0002-3132-0790
Henning BoeckerClinical Functional Imaging Group, Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany.

Funding

Deutsche Forschungsgemeinschaft INST 1172/64-1Medical Faculty of Friedrich-Wilhelms-University Bonn
6 · The paper itself

Abstract

Precise targeting in magnetic resonance-guided focused ultrasound (MRgFUS) is critical for effective tremor control in essential tremor and tremor-dominant Parkinson's disease, as small deviations can reduce efficacy or cause side effects. In our cohort, sweetspots were identified at Montreal Neurological Institute (MNI) coordinates x = -12.4, y = -17.5, z = -1.7 (ET) and x = -13.4, y = -19.8, z = -3.0 (TDPD).

Indexed as

Essential TremorMagnetic Resonance ImagingParkinson DiseaseThalamusTremorAgedCohort StudiesFemaleGermanyHumansMaleMiddle Aged

Identifiers

PMID40778498
PMCPMC12661625

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.