ArticleBiomacromolecules2025
Engineering Bonding Types and Macromeric Cross-Linkers in the Network To Modulate the Structures and Properties of Polydextran/Chitosan Hybrid Hydrogels.
Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Biomedical Hydrogels Based on Oxidized Hyaluronic Acid and Carboxymethyl Chitosan Coordinated with Magnesium Ions.Biomimetics (Basel, Switzerland) · 2026Article
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Authors and funding
3 authors.
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Abstract
Hybrid hydrogels are versatile biomaterials, and cross-linkers are the key for tailoring their characteristics. However, the bonding types in the network and the hydrophobic chain lengths of cross-linkers remain underexplored. This study introduces formylbenzoic acid-modified PEG (PEG-FA), which further reacts with adipic acid (AA), sebacic acid (SA), and tetradecanedioic acid (TDA) to create cross-linkers with varying hydrophobic segments. PEG-FA and its derivatives are used as aldehyde-functionalized macromeric cross-linkers to react with polydextran hydrazide (PDH) and quaternized chitosan (QCS) to form PDH/QCS hybrid hydrogels through dynamic interactions. The results indicate that increasing the hydrazone/imine ratio improves the strength and stability of the network. Notably, TDA-PEG-FA cross-linkers grant hydrogels with smaller pores and better mechanical strength. Overall, the structures and properties of PDH/QCS hydrogels can be tailored by selecting bonding types and designing macromeric cross-linkers in the network, enabling the customization of hydrogel performance for advanced applications.
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