Evidence map›Paper›PMID 40778396›Full record

ReviewFrontiers in sociology2025

Social exclusion and psychopathology in LGBTQ+ communities: a neuropsychosocial review.

Stergios Kaprinis, Anastasios Charalampakis

Abstract readReview
In one paragraph

Review in Frontiers in sociology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Stergios KaprinisSecond Department of Psychiatry, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Anastasios CharalampakisSecond Department of Psychiatry, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LGBTQ+ individuals are disproportionately affected by depression, anxiety, and suicidal ideation, primarily due to persistent social exclusion, prejudice, and systemic discrimination rather than any inherent psychopathology. This review synthesizes contemporary theoretical frameworks, including the Minority Stress Model, the Psychological Mediation Framework, and the Rejection Sensitivity Model, to examine the internalization of systemic marginalization and its manifestation as psychological distress. Significant mediators, such as internalized stigma, emotional dysregulation, and rejection sensitivity, are investigated alongside structural determinants, such as familial rejection and intersectional oppression. Contemporary insights from social psychology, psychiatry, and neuroscience were used in this study. Neurobiological data indicate that chronic minority stress modifies the limbic-prefrontal circuitry, disrupts the hypothalamic- pituitary-adrenal (HPA) axis, and increases allostatic load. The implications for clinical practice and public health were analyzed, emphasizing the importance of community-based resilience initiatives, inclusive policy reforms, and LGBTQ+-affirmative therapy. The article concludes by outlining the theoretical constraints and proposing future avenues for participatory and multidisciplinary studies.

Indexed as

emotional dysregulationinternalized stigmaintersectionalityminority stressneurobiologyrejection sensitivity

Identifiers

PMID40778396
PMCPMC12330642

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.