ArticleNature synthesis2024
Synthesis of Chiral Carbocycles via Enantioselective β,γ-Dehydrogenation.
Article in Nature synthesis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Synthesis of Spiro Carbocycles via Methyl β-C(spJournal of the American Chemical Society · 2026Article
- Enantioselective C-H Activation for the Construction of Chiral Tertiary Fluorides via Migrative Carbofluorination.Journal of the American Chemical Society · 2026Article
- From Mono-Accounts of chemical research · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Enantioselective dehydrogenation of prochiral C-H bonds could provide a powerful method for constructing chiral centers attached to synthetically versatile vinyl groups. Herein, we describe the realization of enantioselective β,γ-dehydrogenation of cycloalkyl amides enabled by chiral oxazoline-pyridone ligands to afford a wide range of highly elaborated carbocycles with exceptional enantioselectivity (>99% ee). Notably, the resulting chiral β,γ-unsaturated carbocycles are difficult to access via inverse electron demand Diels-Alder reaction. Through ligand control, tandem dehydrogenation and C-H olefination sequence also led to the formation of chiral β-alkylidene-γ-lactam. Remarkably, this catalyst is also compatible with complex biologically significant natural products, including diterpenes and pentacyclic triterpenes, where each enantiomer of our chiral ligand enables site-selective modification at four distinct sites within the E ring.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.