ReviewBiochemistry and biophysics reports2025
The role of circular RNAs in gastric Cancer: Focusing on autophagy, EMT, and their crosstalk.
Review in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Circular RNA MALAT1 as a potential target for antimetastatic therapy.Non-coding RNA research · 2026Review
- Pan-cancer analysis and experimental validation reveal UTP4 as a novel biomarker for gastric cancer.Molecular and clinical oncology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Globally, gastric cancer (GC) is one of the leading causes of cancer-related mortality. GC is a major threat and concern in human societies because of the high degree of metastasis and the lack of primary diagnostic biomarkers. EMT (epithelial‒mesenchymal transmission) and autophagy through different signaling pathways can regulate GC metastasis. There is evidence that there is an association and crosstalk between EMT and autophagy. EMT-related signaling pathways affect the autophagy process. Conversely, depending on the tissue and stage of the tumor, autophagy has a dual role and can induce/inhibit EMT by modulating different signaling networks. Recent research has shown that circular RNAs (circRNAs) can affect autophagy, EMT, and crosstalk by modulating multiple signaling molecules. Thus, elucidating the interplay between EMT and autophagy and the association of circRNAs with these processes could provide new goals for the identification of biomarkers and the treatment of GC. This review comprehensively discusses the impact of EMT and autophagy on the onset and progression of GC, the functional role of circRNAs as inhibitors/activators, their regulatory mechanisms in regulating autophagy and EMT, and their potential applications as diagnostic biomarkers or anti-GC treatments. Thus, repressing EMT with circRNA-based autophagy inhibitor/activator drugs may be a new strategy that provides insights into the treatment of GC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.