ArticleToxicology reports2025
Analysing the acute toxicity of e-cigarette liquids and their vapour on human lung epithelial (A549) cells
Article in Toxicology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Vaping-related lung disease: a narrative review.Journal of thoracic disease · 2026Review
- Vape-Associated lncRNA Transcript 1 (VALT1) Amplifies the Tumorigenic Effects of e-Cigarette Vapor in Lung Epithelial Cells.Non-coding RNA · 2026Article
- Diverse Impact of E-Cigarette Aerosols on Oxidative Stress and Inflammation in Lung Alveolar Epithelial Cells (A549).International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of alternative tobacco products such as vaping devices has significantly increased over the last 5-years, with the largest increase being amongst 18-25-year-olds. While the quantity of nicotine is tightly regulated, the composition of e-liquid flavourings is largely unregulated, and often absent from product labels. Herein, we compare the toxicity of carrier liquids propylene glycol (PG) & vegetable glycerine (VG) with five popular flavour concentrates: menthol, cherry, butterscotch, vanilla bourbon and tobacco on human alveolar type II cell-like A549 cells. The flavourings were tested in both liquid and vapour form and a vapour assay was developed to assess cytotoxicity of the flavourings. Our results conclude that menthol liquid was the most cytotoxic (LD
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.