ArticleFrontiers in endocrinology2025
Associations of diabetes mellitus with primary open angle glaucoma and Alzheimer's disease: a large cohort study in UK biobank.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Retinitis pigmentosa elicits neurodegeneration within the visual pathway in REEP6 knockout mice.Neural regeneration research · 2026Article
- Beyond intraocular pressure: vascular and metabolic modifiers of optic nerve vulnerability in glaucoma.International ophthalmology · 2026Review
- Cargo molecules in plasma neural-derived extracellular vesicles reveal pathological signatures of primary open-angle glaucoma.Journal of translational medicine · 2026Article
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7 authors.
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Abstract
Background: Recent studies suggest that the diabetes might be associated with higher risk for primary open angle glaucoma (POAG) and Alzheimer's disease (AD). However, studies have not addressed the critical issue of confounding by indication, and associations have not been evaluated in a large cross-sectional study. We started this cross-sectional study included United Kingdom Biobank (UKBB) participants with complete data (2006-2010) for analysis to explore the associations between diabetes mellitus (DM) and POAG and AD by considering depression and diabetic retinopathy (DR) as intermediate factors. Methods: 28,112 diabetes patients and 471,869 controls without diabetes were included from UKBB. Data on diagnosis of glaucoma, diabetes, depression, Alzheimer's disease, diabetic retinopathy, apolipoprotein E ( Results: Depression, AD, and POAG were more prevalent in participants with DM compared with non-DM participants, and if DM patients had DR, the prevalence of those comorbidities was even higher than those without DR (all p<0.05). DM, DR, AD, and POAG were more prevalent in participants with depression compared with non-depression participants. Specifically, if DM patients had depression, the prevalence of DR and AD were even higher than those without depression (all p<0.05). In addition, using age-adjusted multivariable general linear model (GLM), we found DM and depression were associated with a higher prevalence of POAG in females while DM and Conclusions: DR and depression, as comorbidities related to blood-retinal barrier and blood-brain barrier impairment in patients with DM, may play pivotal roles in the development of POAG and AD among DM patients.
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