Evidence map›Paper›PMID 40778259›Full record

ArticleACS catalysis2024

Ligand-Controlled Nondirected

Guangrong Meng, Jie-Lun Yan, Nikita Chekshin, Daniel A Strassfeld, Jin-Quan Yu

Abstract read
In one paragraph

Article in ACS catalysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Elucidating Ligand-Dependent Selectivities in Pd-Catalyzed C-H Activations.Angewandte Chemie (International ed. in English) · 2025
    Article
  3. Sterically Controlled C(spOrganic letters · 2025
    Article
  4. From Mono-Accounts of chemical research · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guangrong MengDepartment of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0002-3023-0654
Jie-Lun YanDepartment of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0003-3340-2746
Nikita ChekshinDepartment of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.ORCID 00000-0002-9687-3310
Daniel A StrassfeldDepartment of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
Jin-Quan YuDepartment of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0003-3560-5774

Funding

Catalyst-Controlled Site-Selective C-H Functionalizations of Arenes and HeteroarenesR01GM102265 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI YU, JIN-QUAN · 2012 to 2023
$4.6M
Pd-Catalyzed C(sp3)-H Functionalizations Directed by Free Alcohols and Boc-Protected AminesF32GM143921 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI STRASSFELD, DANIEL AARON · 2022 to 2023
$137k
NIGMS NIH HHS F32 GM143921NIGMS NIH HHS R01 GM102265
6 · The paper itself

Abstract

Recent advances in ligand design have enabled Pd(II)-catalyzed non-directed C-H functionalization using arenes as the limiting reagent, but achieving catalyst control over the site-selectivity in these transformations remains a significant challenge. Instead, selectivity is typically governed by the inherent steric and electronic properties of the arene substrates or directing effects. Consequently, it can be difficult to selectively functionalize

Indexed as

C−H activationligand designnon-directedolefinationpalladiumphenols

Identifiers

PMID40778259
PMCPMC12330292

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.