ArticlemedRxiv : the preprint server for health sciences2025
Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.
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Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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262 authors.
Alicia Huerta-ChagoyaPrograms in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 2142, USA.
Joohyun KimVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Ravi MandlaPrograms in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 2142, USA.ORCID 0000-0002-0782-0138
Yingchang LuVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Ken SuzukiDepartment of Statistical Genetics, Osaka University, Osaka, 565-0871, Japan.
Lauren E PettyVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Hong Kiat NgLee Kong Chian School of Medicine, Clinical Sciences Building, Nanyang Technological University, Singapore, 308232, Singapore.
Jaewon ChoiDepartment of Internal Medicine, Seoul National University Hospital, Seoul, 3080, South Korea.
Simon LeeThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Madhusmita RoutDepartment of Pediatrics, Section of Genetics, University of Oklahoma, Oklahoma, OK, USA.
Kuang LinNuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Linda S AdairDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Adebowale AdeyemoCenter for Research on Genomics and Global Health, National Human Genome Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3105-3231
Habibul AhsanBiological Sciences Division, Public Health Sciences, The University of Chicago, Chicago, IL, 60637, USA.
Masato AkiyamaLaboratory for Statistical Analysis, RIKEN Centre for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Ping AnDivision of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA.
Sonia S AnandDepartment of Medicine, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-3692-7441
Diane M BeckerDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Alain G BertoniDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Zheng BianChinese Academy of Medical Sciences, Beijing, 100730, China.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
John BlangeroHuman Genetics and STDOI, University of Texas Rio Grande Valley, Edinburg, TX, USA.ORCID 0000-0001-6250-5723
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Erwin P BottingerDigital Health Center, Digitl Engineering Faculty of Hasso Plattner Institue and University Potsdam, Potsdam, Germany.
Donald W BowdenCenter for Diabetes Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Fiona BraggNuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.ORCID 0000-0002-9181-6886
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Thomas A BuchananDepartment of Medicine, Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Brian E CadeDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-1424-0673
Jin-Fang ChaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
John C ChambersLee Kong Chian School of Medicine, Clinical Sciences Building, Nanyang Technological University, Singapore, 308232, Singapore.
Giriraj R ChandakGenomic Research on Complex diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India.
Li-Ching ChangInstitute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Kyong-Mi ChangDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID 0000-0001-6811-9364
Miao-Li CheeSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.
Chien-Hsiun ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Yuan-Tsong ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Zhengming ChenNuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Yii-Der I ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Ji ChenWellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
Guanjie ChenCenter for Research on Genomics and Global Health, National Human Genome Institute, National Institutes of Health, Bethesda, MD, USA.
Shyh-Huei ChenDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Wei-Min ChenDepartment of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Ching-Yu ChengOphthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore.
Yoon Shin ChoBiomedical Science, Hallym University, Chuncheon, 24252, South Korea.
Hyeok Sun ChoiBiomedical Science, Hallym University, Chuncheon, 24252, South Korea.
Lee-Ming ChuangDepartment of Internal Medicine, Division of Endocrinology and Metabolism, National Taiwan University Hospital, Taipei, Taiwan.
Miguel CruzUnidad de Investigación Médica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
Mary CushmanDepartment of Medicine, University of Vermont, Colchester, VT, USA.
Swapan K DasDepartment of Internal Medicine, Section on Endocrinology and Metabolism, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Ralph A DeFronzoDepartment of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
H Janaka deSilvaDepartment of Medicine, Faculty of Medicine, University of Kelaniya, Sri Lanka.
Latchezar DimitrovCenter for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Ayo P DoumateyCenter for Research on Genomics and Global Health, National Human Genome Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-9494-7710
Shufa DuDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Qing DuanDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Ravindranath DuggiralaHuman Genetics and STDOI, University of Texas Rio Grande Valley, Edinburg, TX, USA.
Leslie S EmeryDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
James C EngertDepartment of Medicine, McGill University, Montreal, QC, Canada.
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Michele K EvansLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.ORCID 0000-0002-8546-2831
Sarah FinerWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Jose C FlorezPrograms in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 2142, USA.
James S FloydCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Myriam FornageInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0003-0677-8158
Elizabeth G FrankelVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Barry I FreedmanDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Lourdes García-GarcíaInstituto Nacional de Salud Pública, Cuernavaca, Mexico.
Pauline GenterDivision of Endocrinology & Metabolism, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Hertzel C GersteinDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Mark O GoodarziDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Penny Gordon-LarsenDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Mariaelisa GraffDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Myron GrossDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55454, USA.
Yu GuoChinese Academy of Medical Sciences, Beijing, 100730, China.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Yang HaiThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Craig L HanisHuman Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
MGeoffrey HayesDepartment of Anthropology, Northwestern University, Evanston, IL, USA.
Momoko HorikoshiLaboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Annie-Green HowardDepartment of Biostatistics, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Sarah HsuPrograms in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 2142, USA.
Willa HsuehDepartment of Internal Medicine, Diabetes and Metabolism Research Center, Ohio State University Wexner Medical Center, Columbus, OH, USA.
Wei HuangShanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies (SIBPT), Shanghai, 200032, China.
Mengna HuangCenter for Global Cardiometabolic Health, Brown University, Providence, RI, USA.
Yi-Jen HungDivision of Endocrine and Metabolism, Tri-Service General Hospital Songshan Branch, Taipei, Taiwan.
Mi Yeong HwangDepartment of Precision Medicine, Division of Genome Science, National Institute of Health, Chungcheongbuk-do, 28159, Republic of Korea.
Chii-Min HwuDepartment of Medicine, Section of Endocrinology and Metabolism, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID 0000-0002-8209-9627
Sahoko IchiharaDepartment of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, 329-0498, Japan.
Michiya IgaseDepartment of Anti-aging Medicine, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan.
Eli IppDivision of Endocrinology & Metabolism, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Mohammad T IslamU Chicago Research, Uttara, Dhaka, 1230, Bangladesh.
Masato IsonoDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
Hye-Mi JangDepartment of Precision Medicine, Division of Genome Science, National Institute of Health, Chungcheongbuk-do, 28159, Republic of Korea.
Farzana JasmineBiological Sciences Division, Public Health Sciences, The University of Chicago, Chicago, IL, 60637, USA.
Jost B JonasRothschild Foundation Hospital, Paris, France.
Yoonjung Y JooDepartment of Health and Biomedical Informatics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Edmond KabagambeDepartment of Medicine, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Takashi KadowakiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8654, Japan.
Yoichiro KamataniLaboratory for Statistical and Translational Genetics, RIKEN Centre for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Fouad R KandeelDepartments of Clinical Diabetes, Endocrinology & Metabolism and Translational Research and Cellular Therapeutics, City of Hope, Duarte, CA, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Elizabeth W KarlsonDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, 2215, USA.
Anuradhani KasturiratneDepartment of Public Health, Faculty of Medicine, University of Kelaniya, Sri Lanka.
Norihiro KatoDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
Tomohiro KatsuyaDepartment of Clinical Gene Therapy, Osaka University, Osaka, 565-0871, Japan.
Varinderpal KaurPrograms in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 2142, USA.
Takahisa KawaguchiCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Jacob M KeatonCenter for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Abel N KhoCenter for Health Information Partnerships, Institute for Public Health and Medicine, Northwestern UniversityFeinberg School of Medicine, Chicago, IL, USA.
Chiea-Chuen KhorGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore.
Muhammad KibriyaBiological Sciences Division, Public Health Sciences, The University of Chicago, Chicago, IL, 60637, USA.
Bong-Jo KimDepartment of Precision Medicine, Division of Genome Science, National Institute of Health, Chungcheongbuk-do, 28159, Republic of Korea.
Woon-Puay KohHealth Services and Systems Research, Duke-NUS Medical School, Singapore, 169857, Singapore.
Katsuhiko KoharaDepartment of Regional Resource Management, Ehime University Faculty of Collaborative Regional Innovation, Ehime, 790-8577, Japan.
Jaspal S KoonerDepartment of Cardiology, Ealing Hosptial, London North West Healthcare NHS Trust, Middlesex, UB1 3HW, UK.
Charles KooperbergFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Raymond J KreienkampPrograms in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 2142, USA.
Amel LamriDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Leslie A LangeDepartment of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Nanette R LeeDepartment of Anthropology, Sociology and History, University of San Carlos, Cebu City, 6000, Philippines.
Myung-Shik LeeSeverance Biomedical Science Institute and Department of Internal Medicine, Yonsei University College of Medicine, Seoul, 3722, South Korea.
Jung-Jin LeeTranslational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Donna M LehmanDepartment of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Liming LiDepartment of Epidemiology and Biostatistics, Peking University Health Science Centre, Beijing, 100191, China.
Yun LiDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Victor Jy LimSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Jianjun LiuGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore.
Yongmei LiuDepartment of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.
Simin LiuDepartment of Epidemiology and Biostatistics, The Joe Wen School of Population & Pubic Health, UCI, Irvine, CA, USA.ORCID 0000-0003-2098-3844
Jirong LongDepartment of Medicine, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Tin LouieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Xi LuoDepartment of Biostatistics and Data Science, University of Texas Health Science Center at Houston, Houston, TX, USA.
Jun LvDepartment of Epidemiology and Biostatistics, Peking University Health Science Centre, Beijing, 100191, China.
Julie A LynchSalt Lake City VA Medical Center, Salt Lake City, UT, USA.
Shiro MaedaLaboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Anubha MahajanWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.
Nisa M MaruthurDepartment of Medicine and Epidemiology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Fumihiko MatsudaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Mark I McCarthyWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.
Roberta McKean-CowdinDepartment of Preventative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
James B MeigsPrograms in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 2142, USA.
Iona Y MillwoodNuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Karen L MohlkeDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Ayesha A MotalaDepartment of Diabetes and Endocrinology, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Girish N NadkarniThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jerry L NadlerDepartment of Medicine and Endocrinology Division, University of California Davis School of Medicine, Sacramento, CA, USA.
Masahiro NakatochiDepartment of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, 461-8673, Japan.ORCID 0000-0002-1838-4837
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Uma NayakDepartment of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA.
Aude NicolasLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Darryl NousomeDepartment of Preventative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Tokyo, 565-0871, Japan.ORCID 0000-0002-0311-8472
Ian PanDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
James S PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA.
Guillaume ParéDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-6795-4760
Jaehyun ParkVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Kyong Soo ParkDepartment of Internal Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, 3080, South Korea.
Esteban J ParraDepartment of Anthropology, University of Toronto at Mississauga, Mississauga, Canada.
Sanjay R PatelDepartment of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Mark A PereiraDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Fraser J PirieDepartment of Diabetes and Endocrinology, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Michael PreussThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michael A ProvinceDivision of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, WA, USA.
Leslie J RaffelDepartment of Pediatrics, Division of Genetic and Genomic Medicine, UCI Irvine School of Medicine, Irvine, CA, USA.
Laura M RaffieldDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0002-7892-193X
Laura J Rasmussen-TorvikDepartment of Preventive Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-0820-7300
Susan RedlineDivision of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Stephen S RichDepartment of Genome Sciences, University of Virginia, Charlottesville, VA, USA.
Rebecca RohdeDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kathryn RollThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Rashedeh RoshaniVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Charles N RotimiCenter for Research on Genomics and Global Health, National Human Genome Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-5759-053X
Charumathi SabanayagamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.
Danish SaleheenDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Kevin SandowThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Claudia SchurmannDigital Health Center, Digitl Engineering Faculty of Hasso Plattner Institue and University Potsdam, Potsdam, Germany.
Mohammad ShahriarBiological Sciences Division, Public Health Sciences, The University of Chicago, Chicago, IL, 60637, USA.
Douglas M ShawVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Wayne H-H SheuSchool of Medicine, National Defense Medical Center, Taipei, Taiwan.
Jinxiu ShiShanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies (SIBPT), Shanghai, 200032, China.
Xiao-Ou ShuDepartment of Medicine, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Megan M ShueyVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Moneeza K SiddiquiWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-3575-5468
Tamar SoferDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0001-8520-8860
Cassandra N SpracklenDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0003-3590-7182
Adrienne M StilpDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Meng SunNuffield Department of Surgical Sciences, University of Oxford, Oxford, OX3 9DU, UK.
Yasuharu TabaraCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
E-Shyong TaiDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Salman M TajuddinLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Atsushi TakahashiLaboratory for Statistical and Translational Genetics, RIKEN Centre for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Fumihiko TakeuchiDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.ORCID 0000-0003-3185-5661
Jingyi TanThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Katherine TaylorPrograms in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 2142, USA.
Farook ThameemDepartment of Biochemistry, Faculty of Medicine, Health Science Center, Kuwait University, Safat, Kuwait.
Lin TongBiological Sciences Division, Public Health Sciences, The University of Chicago, Chicago, IL, 60637, USA.
Fuu-Jen TsaiDepartment of Medical Genetics and Medical Research, China Medical University Hospital, Taichung, 40402, Taiwan.
Philip S TsaoDepartment of Medicine, Stanford University, Palo Alto, CA, USA.
Miriam S UdlerPrograms in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 2142, USA.
Adan Valladares-SalgadoUnidad de Investigación Médica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
David A van HeelBlizard Institute, Queen Mary University of London, London, UK.ORCID 0000-0002-0637-2265
Rob M vanDamSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Rohit VarmaSouthern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, CA, USA.
Maheak VoraPrograms in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 2142, USA.
Niels Wacher-RodarteUnidad de Investigación Médica en Epidemiologia Clinica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
Ya-Xing WangBeijing Institute of Ophthalmology, Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, 100005, China.
Ellie WheelerMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ananda R WickremasingheDepartment of Public Health, Faculty of Medicine, University of Kelaniya, Sri Lanka.
Genevieve L WojcikDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Tien Y WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.
Jer-Yuarn WuInstitute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Yong-Bing XiangState Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200032, China.
Anny H XiangDepartment of Research & Evaluation, Division of Biostatistics Research, Kaiser Permanente of Southern California, Pasadena, CA, USA.
Chittaranjan S YajnikDiabetes Unit, King Edward Memorial Hospital and Research Centre, Pune, India.ORCID 0000-0002-2911-2378
Ken YamamotoDepartment of Medical Biochemistry, Kurume University School of Medicine, Kurume, 830-0011, Japan.
Toshimasa YamauchiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8654, Japan.
Lisa R YanekDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.ORCID 0000-0001-7117-1075
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Mitsuhiro YokotaDepartment of Medical Biochemistry, Kurume University School of Medicine, Kurume, 830-0011, Japan.
Canqing YuDepartment of Epidemiology and Biostatistics, Peking University Health Science Centre, Beijing, 100191, China.
Jian-Min YuanDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, 15232, USA.
Salim YusufDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Eleftheria ZegginiInstitute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Liang ZhangSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.
Weihua ZhangDepartment of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.ORCID 0000-0003-1226-070X
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
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Genes & Health Research Team
VA Million Veteran Program
Carlos A Aguilar-SalinasUnidad de Investigación de Enfermedades Metabólicas, Research Direction of the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Clicerio González-VillalpandoCentro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Pública, Mexico City, Mexico.
Christopher A HaimanDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.
Young Jin KimDepartment of Precision Medicine, Division of Genome Science, National Institute of Health, Chungcheongbuk-do, 28159, Republic of Korea.ORCID 0000-0002-4132-4437
Soo Heon KwakDepartment of Internal Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, 3080, South Korea.
Aaron LeongPrograms in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 2142, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andres Moreno-EstradaAging Research Center, Cinvestav Sede Sur, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico.
Andrew P MorrisCentre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.
Lorena OrozcoInstituto Nacional de Medicina Genómica, Mexico City, Mexico.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Dharambir SangheraDepartment of Pediatrics, Section of Genetics, University of Oklahoma, Oklahoma, OK, USA.
Teresa Tusie-LunaUnidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Benjamin F VoightCorporal Michael J. Crescenz Philadelphia VA Medical Center, Philadelphia, PA, USA.ORCID 0000-0002-6205-9994
Marijana VujkovicDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID 0000-0003-4924-5714
Robin G WaltersNuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.ORCID 0000-0002-9179-0321
Tian GePsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 2114, USA.
Alisa K ManningClinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, 2114, USA.
Marie LohLee Kong Chian School of Medicine, Clinical Sciences Building, Nanyang Technological University, Singapore, 308232, Singapore.
Jennifer E BelowVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Josep M MercaderPrograms in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 2142, USA.ORCID 0000-0001-8494-3660
Maggie C Y NgVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
D-PRISM Consortium
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MFunctional Interrogation of T2D-associated genes in human stem cell-derived models and miceUM1DK126194 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GRANT, STRUAN F A, KAESTNER, KLAUS H · 2020 to 2024
$8.8MProspective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0MGenetics of African American Type 2 DiabetesR01DK066358 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NG, MAGGIE · 2003 to 2019
$6.2MHispanic Latino Lipid ConsortiumR01HL142302 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jennifer Below, JOSEPH MCCORMICK · 2018 to 2026
$5.8MDevelopment of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple AncestriesU01HG011723 · NHGRI · BROAD INSTITUTE, INC. · PI Alisa Knodle Manning, Josep Maria Mercader · 2021 to 2026
$5.7MTHE SINGAPORE COHORT STUDY OF DIET AND CANCERR01CA080205 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YUAN, JIAN-MIN · 1999 to 2009
$5.3MSOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0MGenetic programming of human islet metabolic and endoplasmic reticulum (ER) stress responses in diabetesR01DK118011 · NIDDK · JACKSON LABORATORY · PI Michael Lee Stitzel · 2021 to 2026
$4.9MCancer epidemiology cohorts in Shanghai and Singapore UM1CA182876 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2014 to 2018
$4.3MNCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NCI NIH HHS R01 CA080205NCI NIH HHS R01 CA144034NCI NIH HHS U01 CA182876NCI NIH HHS U01 CA288325NCI NIH HHS UM1 CA182876NEI NIH HHS R01 EY036258NHGRI NIH HHS U01 HG011723NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL158884NHLBI NIH HHS R01 HL172803NHLBI NIH HHS R56 HL150186NIBIB NIH HHS R01 EB015611NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK066358NIDDK NIH HHS R01 DK118011NIDDK NIH HHS R01 DK135938NIDDK NIH HHS R01 DK136671NIDDK NIH HHS R01 DK137993NIDDK NIH HHS R01 DK139598NIDDK NIH HHS U01 DK105556NIDDK NIH HHS U01 DK140757NIDDK NIH HHS UM1 DK126194
Abstract
Background: Polygenic risk scores (PRSs) improve type 2 diabetes (T2D) prediction beyond clinical risk factors but perform poorly in non-European populations, where T2D burden is often higher, undermining their global clinical utility. Methods: We conducted the largest global effort to date to harmonize T2D genome-wide association study (GWAS) meta-analyses across five ancestries-European (EUR), African/African American (AFR), Admixed American (AMR), South Asian (SAS), and East Asian (EAS)-including 360,000 T2D cases and 1·8 million controls (41% non-EUR). We constructed ancestry-specific and multi-ancestry PRSs in training datasets including 11,000 T2D cases and 32,000 controls, and validated their performance in independent datasets including 39,000 T2D cases and 126,000 controls of diverse ancestries. In the All of Us Research Program, we compared these PRSs to those from the Polygenic Score Catalog and assessed their ability to predict diabetes micro- and macrovascular complications. Findings: Ancestry-specific PRSs showed limited prediction power for T2D in AFR, AMR, and SAS compared to EUR and EAS. In contrast, multi-ancestry PRSs, built using GWAS data from five ancestries, substantially improved T2D prediction across all ancestries. Compared to those in the interquartile range, individuals at the 97·5 Interpretation: We developed and extensively validated the most up-to-date T2D PRSs across diverse ancestry groups. These PRSs are publicly available to support further evaluation of their clinical utility in diverse ancestries.
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