Evidence map›Paper›PMID 40778142›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Post head and neck cancer radiation therapy dynamic contrast enhanced magnetic resonance imaging association with high mandibular radiation dose.

Brandon Reber, Renjie He, Moamen R Abdelaal, Abdallah Mohamed, Sam Mulder, Laia Humbert Vidan, Clifton D Fuller, Stephen Y Lai, Kristy Brock

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Brandon ReberDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, US0041.ORCID 0000-0001-9935-2273
Renjie HeDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-9166-6286
Moamen R AbdelaalThe University of Rochester, Rochester, New York, USA.ORCID 0000-0003-4476-2122
Abdallah MohamedDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0003-2064-7613
Sam MulderDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-6981-9925
Laia Humbert VidanDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-8005-6770
Clifton D FullerDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-5264-3994
Stephen Y LaiDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-8301-7286
Kristy BrockDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, US0041.ORCID 0000-0001-9364-5040

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Establish Objective Clinical Outcome Measures for Mandibular OsteoradionecrosisR01DE025248 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LAI, STEPHEN Y · 2016 to 2020
$2.9M
NCI NIH HHS P30 CA016672NIDCR NIH HHS R01 DE025248
6 · The paper itself

Abstract

Background: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is a functional imaging modality that can quantify tissue permeability and blood flow. Due to vasculature changes resulting from radiation therapy (RT), DCE-MRI quantitative parameters should be significantly different in regions receiving a high radiation dose compared to regions receiving a low radiation dose. This work sought to determine if a significant difference exists in post head and neck cancer (HNC)-RT DCE-MRI quantitative parameters Methods: DCE-MRI was acquired from HNC subjects post-RT. The DCE-MRI quantitative parameters Results: 48 HNC subjects were included in the analysis. The Kruskal-Wallis tests showed no inherent significant difference in Conclusions: No inherent difference in DCE-MRI quantitative parameters was observed within subject mandibles, but a significant difference was observed between v

Indexed as

dynamic contrast-enhanced MRIHead and neck cancermandibleradiation

Identifiers

PMID40778142
PMCPMC12330453

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.